School of Pharmacy, Kumamoto University, Kumamoto, Japan.
Program for Leading Graduate Schools, Health life sciences: Interdisciplinary and Glocal Oriented (HIGO) Program, Kumamoto University, Kumamoto, Japan.
Nat Prod Res. 2022 Aug;36(15):4036-4039. doi: 10.1080/14786419.2021.1903004. Epub 2021 Mar 24.
(L.) Kitam. var. (Siebold et Zucc.) Kitam. is mainly distributed in the Kyushu and Shikoku Islands of Japan. The main aim of this study was to isolate and identify the chemical constituents of the 70% EtOH extract of the flowers of var. and to evaluate their tyrosinase inhibitory and free radical scavenging activities. Five phenolic compounds, namely petasiphenol (), rosmarinic acid (), 4,5-di--caffeoylquinic acid (), 5--caffeoylquinic acid () and quercetin () were isolated and their structures were elucidated on the basis of NMR spectroscopic data. All these compounds were isolated for the first time from title plant. Among them, petasiphenol () showed potent tyrosinase inhibitory activity followed by quercetin () and 4,5-di--caffeoylquinic acid (). All of these compounds showed potent free radical scavenging activity.
(L.) Kitam. var. (Siebold et Zucc.) Kitam. 主要分布在日本九州和四国地区。本研究的主要目的是从该变种的花的 70%乙醇提取物中分离并鉴定其化学成分，并评估它们对酪氨酸酶的抑制和自由基清除活性。分离得到了 5 种酚类化合物，分别为 petasiphenol (), rosmarinic acid (), 4,5-二--咖啡酰奎宁酸 (), 5--咖啡酰奎宁酸 () 和槲皮素 ()，并根据 NMR 谱数据阐明了它们的结构。所有这些化合物均首次从该植物中分离得到。其中，petasiphenol () 对酪氨酸酶的抑制活性最强，其次是槲皮素 () 和 4,5-二--咖啡酰奎宁酸 ()。所有这些化合物均表现出较强的自由基清除活性。
