Laboratoire de Biomathématiques, Biophysique, Biochimie, et Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria.
Laboratoire de Microbiologie Appliquée (LMA), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria.
Molecules. 2023 May 22;28(10):4243. doi: 10.3390/molecules28104243.
The emergence of the antimicrobial resistance phenomena on and the harmful consequences of the use of antibiotics motivate the necessity of innovative antimicrobial therapies, while natural substances are considered a promising alternative. Rosmarin is an original plant compound listed among the hydroxycinnamic acids. This substance has been widely used to fight microbial pathology and chronic infections from microorganisms like bacteria, fungi and viruses. Also, various derivatives of rosmarinic acid, such as the propyl ester of rosmarinic acid, rosmarinic acid methyl ester or the hexyl ester of rosmarinic acid, have been synthesized chemically, which have been isolated as natural antimicrobial agents. Rosmarinic acid and its derivatives were combined with antibiotics to obtain a synergistic effect. This review reports on the antimicrobial effects of rosmarinic acid and its associated derivatives, both in their free form and in combination with other microbial pathogens, and mechanisms of action.
抗菌药物耐药性现象的出现及其使用的有害后果促使人们需要开发创新的抗菌疗法，而天然物质被认为是一种很有前途的替代物。迷迭香是一种羟基肉桂酸类的原始植物化合物。这种物质已被广泛用于对抗微生物病理学和由细菌、真菌和病毒等微生物引起的慢性感染。此外，迷迭香酸的各种衍生物，如迷迭香酸丙酯、迷迭香酸甲酯或迷迭香酸己酯，已通过化学方法合成，并已被分离为天然的抗菌剂。迷迭香酸及其衍生物与抗生素联合使用以获得协同作用。本综述报告了迷迭香酸及其相关衍生物的抗菌作用，包括游离形式和与其他微生物病原体联合使用的情况，以及作用机制。
