感染曼氏血吸虫的母亲哺乳可恢复 IgG2a 和 TGF-β的产生，但不能恢复 IL-12/IL-23 缺陷型小鼠的 IL-6 和迟发型超敏反应。
Suckling by Schistosoma mansoni-infected mothers restored IgG2a and TGF-β production, but not IL-6 and delayed-type hypersensitivity in IL-12/IL-23-deficient mice.
机构信息
Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Laboratório de Imunopatologia e Biologia Molecular, Recife, PE, Brasil.
Universidade Federal de Pernambuco, Laboratório de Imunopatologia Keizo Asami, Setor de Imunologia, Recife, PE, Brasil.
出版信息
Rev Soc Bras Med Trop. 2021 Mar 22;54:e0744-2020. doi: 10.1590/0037-8682-0744-2020. eCollection 2021.
INTRODUCTION
Suckling by schistosomotic mice improves anti-ovalbumin (OA) antibody production, while delayed-type hypersensitivity (DTH) remains unaffected. This property of milk from schistosomotic mice was investigated in IL-12/IL-23-deficient mice (IL-12p40KO).
METHODS
We compared anti-OA DTH, IgG2a and cytokines in wild-type and IL-12p40KO mice suckled by infected (SIM) or non-infected (CONTROL) mothers.
RESULTS
SIM mice showed similar intensity and eosinophils in the DTH, which was abolished in IL-12p40KO and IL-12p40KO-SIM mice. In IL-12p40KO-SIM, IgG2a and TGF-β levels were higher, but IL-6 levels were lower.
CONCLUSIONS
Milk from schistosomotic mothers may evoke IgG2a without eliciting DTH in IL-12/IL-23 deficiencies, by changing TGF-β/IL-6 levels.
简介
感染血吸虫的老鼠的哺乳行为可提高抗卵清蛋白（OA）抗体的产生，而迟发型超敏反应（DTH）则不受影响。本研究旨在探究感染血吸虫的老鼠的乳汁是否具有这一特性，并在白细胞介素-12/23 缺陷（IL-12p40KO）的小鼠中进行了研究。
方法
我们比较了感染（SIM）或未感染（CONTROL）母亲哺乳的野生型和 IL-12p40KO 小鼠的抗 OA DTH、IgG2a 和细胞因子。
结果
SIM 组小鼠的 DTH 反应强度和嗜酸性粒细胞数量相似，而在 IL-12p40KO 和 IL-12p40KO-SIM 组中则被消除。在 IL-12p40KO-SIM 组中，IgG2a 和 TGF-β 的水平较高，但 IL-6 的水平较低。
结论
在 IL-12/IL-23 缺陷的情况下，来自感染血吸虫的母亲的乳汁可能通过改变 TGF-β/IL-6 水平来诱导 IgG2a 的产生，而不引起 DTH。
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