Department of Vascular Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
Department of Plastic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
Mol Med Rep. 2021 May;23(5). doi: 10.3892/mmr.2021.12029. Epub 2021 Mar 24.
Burn wounds present an evolutionary progression, in which the initial wound tissue deepens and expands following thermal injury. Progressive tissue damage in the zone of stasis may worsen burn injury, which is associated with oxidative stress and secondary apoptosis, and worsen the prognosis of patients with burn wounds. The mitochondrial apoptotic pathway is involved in receiving oxidative signals and regulating tissue apoptosis. Previously, Abnormal Savda Munziq (ASMq), a natural compound of traditional Uyghur Medicine, which includes ten types of herb, has been reported to exhibit a number of effects, including anti‑inflammatory, antioxidative and anti‑apoptotic activities. The present study demonstrated that ASMq protected against early burn wound progression following thermal injury in rats; this effect may be mediated by its ability to attenuate oxidative stress‑induced mitochondria‑associated apoptosis. The present study may provide a novel therapeutic method to prevent early burn wound progression following burn injury.
烧伤创面呈进行性加深扩大，在热力损伤后，初始创面组织加深扩大。淤滞带组织进行性损伤可加重烧伤，与氧化应激和继发性细胞凋亡有关，使烧伤患者的预后恶化。线粒体凋亡途径参与接受氧化信号和调节组织凋亡。先前有报道称，异常黑胆质成熟剂（ASMq）是一种包含 10 种草药的传统维吾尔医学天然化合物，具有抗炎、抗氧化和抗凋亡作用。本研究表明，ASMq 可防止大鼠热损伤后早期烧伤创面进展；这种作用可能是通过减轻氧化应激诱导的线粒体相关凋亡来介导的。本研究可能为预防烧伤后早期烧伤创面进展提供一种新的治疗方法。
