Maes L, Coussement W, Desplenter L, Marsboom R
Janssen Pharmaceutica NV, Beerse, België.
Tijdschr Diergeneeskd. 1988 Feb 15;113(4):195-204.
In a six-month study, the safety of repeated treatments with clazuril, a new anticoccidial agent for the treatment of pigeons, was evaluated during 4 to 5 consecutive reproduction cycles. Clazuril was administered weekly at the recommended therapeutic dose level of 2.5 mg/pigeon and at twice this dose. The results were compared to placebo treatment. Evaluation was based on the following parameters: reproductive behaviour, egg laying, fertilisation, embryonic mortality, hatching, percentage of weaning and time interval between consecutive reproductive cycles. Maternal-paternal toxicity (body weight evolution, feather coat) and tolerance in newborn pigeons (general behaviour, daily gain in body weight, feathering, skeletal anomalies) were also evaluated. In all the treatment groups, reproductive performance was comparable and no drug- or dose-related side-effects were observed. Fertilisation, embryonic mortality and the time-interval between the consecutive reproductive cycles remained within the normal physiological range. Hatched pigeons showed a satisfactory daily weight gain and deaths among these birds were exceptional. Tolerance of clazuril in adult as well as in day-old pigeons was exceptionally good and body weight evolution, feathering and mortality were not adversely affected. No drug-related pathological findings or skeletal anomalies were detected in the animals at autopsy. It can be concluded that repeated treatments with clazuril are entirely harmless for pigeons during reproduction, even at double the therapeutic dose level. Clazuril is well tolerated by newborn and growing pigeons, which means that pigeon house group treatments during reproduction may be performed without any risk.
在一项为期6个月的研究中，对一种用于治疗鸽子的新型抗球虫药氯嗪苯乙氰进行重复治疗的安全性进行了评估，该评估在4至5个连续繁殖周期内进行。氯嗪苯乙氰每周按2.5毫克/只鸽子的推荐治疗剂量水平给药，以及按该剂量的两倍给药。将结果与安慰剂治疗进行比较。评估基于以下参数：繁殖行为、产蛋、受精、胚胎死亡率、孵化、断奶百分比以及连续繁殖周期之间的时间间隔。还评估了亲代毒性（体重变化、羽毛状况）和新生鸽子的耐受性（一般行为、体重日增重、羽毛生长、骨骼异常）。在所有治疗组中，繁殖性能相当，未观察到与药物或剂量相关的副作用。受精、胚胎死亡率以及连续繁殖周期之间的时间间隔均保持在正常生理范围内。孵化出的鸽子体重日增重令人满意，这些鸽子中的死亡情况很少见。氯嗪苯乙氰在成年鸽子和一日龄鸽子中的耐受性都非常好，体重变化、羽毛生长和死亡率均未受到不利影响。尸检时在动物身上未检测到与药物相关的病理发现或骨骼异常。可以得出结论，即使在治疗剂量水平加倍的情况下，氯嗪苯乙氰对繁殖期的鸽子进行重复治疗也完全无害。氯嗪苯乙氰在新生和生长中的鸽子中耐受性良好，这意味着繁殖期间鸽舍分组治疗可以毫无风险地进行。
