Vercruysse J
Faculty of Veterinary Medicine, Department of Parasitology, Gent, Belgium.
Avian Dis. 1990 Jan-Mar;34(1):73-9.
The efficacy of toltrazuril in comparison with clazuril on heavy experimental Eimeria labbeana and E. columbarum infections in pigeons was investigated. The minimum required dose of toltrazuril to completely suppress oocyst excretion is 20 mg/kg body weight for 1 day. After treatment with toltrazuril, there was a dose-dependent period during which pigeons remained negative; at a dosage of 35 mg/kg or higher, this period was at least 4 weeks. Clazuril at the recommended dose of 2.5 mg/pigeon resulted in a rapid suppression of oocyst excretion, but oocysts were again observed in the feces 20 days after treatment. The fact that oocysts appeared again in the feces 3 to 5 weeks after treatment can probably be explained only by a persistence of endogenous stages, which are not affected during treatment, rather than by a reinfection. Reinfection of the previously medicated and infected pigeons 30 days after the first infection provided some data on possible induced immunity.
研究了托曲珠利与氯嗪苯乙腈对鸽严重实验性拉氏艾美耳球虫和鸽艾美耳球虫感染的疗效。完全抑制卵囊排泄所需的托曲珠利最小剂量为20毫克/千克体重，连用1天。用托曲珠利治疗后，存在一个剂量依赖性时期，在此期间鸽子保持阴性；剂量为35毫克/千克或更高时，这个时期至少为4周。推荐剂量为2.5毫克/只鸽的氯嗪苯乙腈可迅速抑制卵囊排泄，但治疗20天后粪便中又观察到卵囊。治疗3至5周后粪便中再次出现卵囊这一事实，可能只能解释为内源性阶段持续存在，这些阶段在治疗期间未受影响，而非再次感染。首次感染30天后对先前用药并感染的鸽子进行再次感染，提供了一些关于可能诱导免疫的数据。
