Vanparijs O, Hermans L, Van der Flaes L, Vlaminck K, Marsboom R
Janssen Pharmaceutica, N.V., Beerse, België.
Tijdschr Diergeneeskd. 1988 Feb 15;113(4):190-4.
The effectiveness of clazuril (Appertex), a new anticoccidial agent for the treatment of pigeons is described in the present study. Clazuril, a benzene-acetonitrile derivative, is administered in a single dose. In laboratory studies, 121 carrier pigeons infected with E. labbeana and E. columbarum were treated once with clazuril in gelatin capsules at dose levels of 10 mg, 5 mg, 2.5 mg, 1.25 mg, 0.63 mg or with a placebo. When a single dose of 2.5 mg and higher was administered, all faecal samples became negative for oocysts within seven days after treatment. In the field studies, 1531 young and full-grown carrier pigeons, from 116 infected dove-cotes, were treated with 1 tablet of 2.5 mg clazuril. Seven days after treatment, the faecal samples of 105 dove-cotes were negative for oocysts of E. Labbeana and E. columbarum; in six dove-cotes, infection was also virtually reduced to zero. Performance in racing was not affected by treatment and side-effects were not observed.
本研究描述了新型抗球虫药氯嗪苯乙腈（克球粉）治疗鸽子的有效性。氯嗪苯乙腈是一种苯乙腈衍生物，采用单剂量给药。在实验室研究中，121只感染拉贝艾美球虫和鸽艾美球虫的信鸽，分别用剂量为10毫克、5毫克、2.5毫克、1.25毫克、0.63毫克的氯嗪苯乙腈明胶胶囊或安慰剂进行单次治疗。当给予2.5毫克及以上单剂量时，所有粪便样本在治疗后7天内卵囊检测呈阴性。在现场研究中，对来自116个受感染鸽舍的1531只幼鸽和成年信鸽，用1片2.5毫克氯嗪苯乙腈进行治疗。治疗7天后，105个鸽舍的粪便样本中拉贝艾美球虫和鸽艾美球虫的卵囊检测呈阴性；在6个鸽舍中，感染率也几乎降至零。治疗对赛鸽表现没有影响，且未观察到副作用。
