Hijzen T H, De Beun R, Slangen J L
Department of Psychophysiology, State University of Utrecht, The Netherlands.
Toxicology. 1988 May;49(2-3):271-6. doi: 10.1016/0300-483x(88)90008-x.
The effects of NAK 1901 (Pentafluorbenzyl (1R, cis)-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-carboxylate) and cypermethrin ((S,R)-alpha-cyano-3-phenoxybenzyl-2,2-dimethyl (1R, 1S, cis, trans)-3-(2,2-dichlorovinyl) cyclopropane-carboxylate) (RU 24 501) on amplitude and prepulse inhibition of the acoustic startle reflex were studied in male Wistar rats. NAK 1901 (0, 1, 2.5, 4 mg/kg p.o.) enhanced the amplitude of the startle reflex in a dose-dependent way. Startle latency was not affected. Cypermethrin (0, 0.5, 1, 2 mg/kg p.o.) had no effect on the amplitude or the latency of the startle reflex. Both NAK 1901 and cypermethrin administration produced a dose-dependent increase in toxic signs and a dose-dependent increase in weight loss during the experimental session. None of the pyrethroids affected prepulse inhibition of the startle reflex. Because the neural substrate of the inhibitory processes involved in prepulse inhibition are probably of supraspinal origin, it is suggested that these substrates are not affected by pyrethroids.
在雄性Wistar大鼠中研究了NAK 1901（五氟苄基(1R,顺式)-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷羧酸酯）和氯氰菊酯（(S,R)-α-氰基-3-苯氧基苄基-2,2-二甲基(1R,1S,顺式,反式)-3-(2,2-二氯乙烯基)环丙烷羧酸酯）（RU 24 501）对听觉惊跳反射的幅度和前脉冲抑制的影响。NAK 1901（0、1、2.5、4毫克/千克，口服）以剂量依赖性方式增强惊跳反射的幅度。惊跳潜伏期未受影响。氯氰菊酯（0、0.5、1、2毫克/千克，口服）对惊跳反射的幅度或潜伏期没有影响。在实验期间，给予NAK 1901和氯氰菊酯均导致中毒体征呈剂量依赖性增加以及体重减轻呈剂量依赖性增加。两种拟除虫菊酯均未影响惊跳反射的前脉冲抑制。由于参与前脉冲抑制的抑制过程的神经基质可能起源于脊髓以上，因此提示这些基质不受拟除虫菊酯的影响。
