School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangzhou, China.
School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangzhou, China.
Complement Ther Clin Pract. 2021 May;43:101371. doi: 10.1016/j.ctcp.2021.101371. Epub 2021 Mar 18.
Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies. A variety of Chinese herbal medicines have shown good protective effects against TA.
To analyze the different prescriptions for TA and summarize the medication rules for such treatment.
Data mining methods including frequency analysis, cluster analysis, factor analysis and association rule learning were used in this study.
In total, 171 herbs and 398 formulas were collected. The most frequently used herbs are Dipsaci Radix (Xuduan, accounts for 7.58%). The top three categories were deficiency-tonifying herbs (29.24%), wind-damp dispelling herbs (12.87%) and heat-clearing herbs (9.94%). Eleven factors and 8 clusters with clinical significance for prescription were formed by factor and cluster analyses.
Tonification methods including spleen and kidney nourishment are the main principles for TA treatment and Shoutai Pill can be used as the basic formula for clinical addition or subtraction.
威胁性流产（TA）是妊娠早期最常见的并发症，影响 20%-25%的妊娠。多种中草药对 TA 显示出良好的保护作用。
分析 TA 的不同处方，总结治疗此类疾病的用药规律。
本研究采用数据挖掘方法，包括频率分析、聚类分析、因子分析和关联规则学习。
共收集到 171 种草药和 398 个方剂。使用最频繁的草药是续断（Xuduan，占 7.58%）。前三大类是补虚药（29.24%）、祛风除湿药（12.87%）和清热药（9.94%）。通过因子和聚类分析，形成了 11 个具有临床意义的因子和 8 个聚类。
补脾肾法是治疗 TA 的主要原则，寿胎丸可作为临床加减的基本方。
