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基于网络药理学的盘基生中药复方治疗炎症的活性成分及作用机制研究

Network Pharmacology-Based Study on the Active Ingredients and Mechanism of Pan Ji Sheng Traditional Chinese Medicine Formula in the Treatment of Inflammation.

作者信息

Wu Shiji, Jiang Hongliang, Chen Zongwen, Lu Weining, Chen Qin

机构信息

Gaozhou Hospital of Traditional Chinese Medicine, No. 32 Maoming Avenue, Gaozhou 525200, Guangdong, China.

出版信息

Evid Based Complement Alternat Med. 2022 Sep 28;2022:5340933. doi: 10.1155/2022/5340933. eCollection 2022.

DOI:10.1155/2022/5340933
PMID:36212968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9534616/
Abstract

BACKGROUND

Pan Ji Sheng Formula is a Chinese medicine formula that enables heat-free detoxification as well as anti-inflammatory and immune-boosting properties. This formula contains eight herbs. Its underlying mechanism is unknown. The bioactive ingredients were screened in our work, and the mechanism of this formula was investigated.

METHODS

Using traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), ingredients in Pan Ji Sheng Chinese medicine formula were screened, and we selected the main bioactive ingredients for web-based research. The targets of bioactive ingredients are primarily obtained from the SwissTargetPrediction and TCMSP databases, and the text mining method is used. STRING and Cytoscape were then used to examine the protein-protein interaction (PPI) networks. To explore the biological function and related pathways, functional annotation and pathway analysis were performed.

RESULTS

This research discovered 96 bioactive ingredients. Then, 215 potential targets of bioactive ingredients were screened. Through the analysis of the PPI network, we discovered 25 key target genes, which can be described as hub target genes regulated by bioactive ingredients. Bioactive ingredients primarily regulate CASP3, AKT1, JUN, and other proteins. The formula works synergistically to enhance immune response and antiinfection by regulating immune-related pathways, TNF signaling pathways, and apoptosis.

CONCLUSIONS

A variety of bioactive ingredients in the formula could play roles in regulating CASP3, AKT1, and other genes in immune, infection, apoptosis, and tumor-related signaling pathways. Our data point the way forward for future studies on the mechanism of action of this formula.

摘要

背景

盘基生方是一种具有清热排毒、抗炎和增强免疫特性的中药方剂。该方剂包含八味草药。其潜在机制尚不清楚。我们在研究中筛选了其生物活性成分，并对该方剂的作用机制进行了研究。

方法

利用中药系统药理学数据库与分析平台（TCMSP）筛选盘基生方中的成分，并选择主要生物活性成分进行网络研究。生物活性成分的靶点主要从SwissTargetPrediction和TCMSP数据库中获取，并采用文本挖掘方法。然后使用STRING和Cytoscape检查蛋白质-蛋白质相互作用（PPI）网络。为了探索生物学功能和相关途径，进行了功能注释和途径分析。

结果

本研究发现了96种生物活性成分。随后，筛选出215个生物活性成分的潜在靶点。通过对PPI网络的分析，我们发现了25个关键靶基因，可将其描述为由生物活性成分调控的枢纽靶基因。生物活性成分主要调节半胱天冬酶3（CASP3）、蛋白激酶B（AKT1）、原癌基因c-Jun（JUN）等蛋白质。该方剂通过调节免疫相关途径、肿瘤坏死因子（TNF）信号通路和细胞凋亡发挥协同作用，增强免疫反应和抗感染能力。

结论

该方剂中的多种生物活性成分可能在免疫、感染、细胞凋亡和肿瘤相关信号通路中调节CASP3、AKT1等基因发挥作用。我们的数据为该方剂作用机制的未来研究指明了方向。

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