State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, PR China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, PR China.
Biomed Pharmacother. 2021 May;137:111372. doi: 10.1016/j.biopha.2021.111372. Epub 2021 Feb 22.
Menopausal women are susceptible to have high risk of cardiovascular diseases, type II diabetes and osteoporosis due to the metabolic disorder caused by estrogen deficiency. Accumulating evidence supports that gut microbiota is a key regulator of metabolic diseases. Our previous metabolomics study interestingly demonstrated that the anti-osteoporotic effects of lignan-rich fraction (SWCA) from Sambucus wialliamsii Hance were related to the restoration of a series of lipid and glucose metabolites. This study aims to investigate how SWCA modulates lipid and glucose metabolism and the underlying mechanism. Our results show that oral administration of SWCA (140 mg/kg and 280 mg/kg) for 10 weeks alleviated dyslipidemia, improved liver functions, prevented glucose tolerance and insulin actions, attenuated system inflammation and improved intestinal barrier in OVX rats. It also induced a high abundance of Actinobacteria, and restored microbial composition. We are the first to report the protective effects of the lignan-rich fraction from S. williamsii on dyslipidemia and insulin resistance. Our findings provide strong evidence for the application of this lignan-rich fraction to treat menopausal lipid disorder and insulin resistance-related diseases.
由于雌激素缺乏引起的代谢紊乱，绝经后妇女易患心血管疾病、II 型糖尿病和骨质疏松症。越来越多的证据支持肠道微生物群是代谢性疾病的关键调节剂。我们之前的代谢组学研究有趣地表明，从黑果忍冬中提取的富含木脂素的部位（SWCA）具有抗骨质疏松作用，这与一系列脂质和葡萄糖代谢物的恢复有关。本研究旨在探讨 SWCA 如何调节脂质和葡萄糖代谢及其潜在机制。我们的结果表明，口服 SWCA（140mg/kg 和 280mg/kg）10 周可缓解血脂异常，改善肝功能，预防葡萄糖耐量和胰岛素作用受损，减轻全身炎症反应，改善 OVX 大鼠的肠道屏障功能。它还诱导了放线菌的高丰度，并恢复了微生物组成。我们是第一个报告黑果忍冬富含木脂素部位对血脂异常和胰岛素抵抗的保护作用的人。我们的研究结果为将这种富含木脂素的部位应用于治疗绝经后脂质紊乱和与胰岛素抵抗相关的疾病提供了有力的证据。
