Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep;397(9):6439-6458. doi: 10.1007/s00210-024-03102-x. Epub 2024 May 2.
Lignans are biologically active compounds widely distributed, recognized, and identified in seeds, fruits, and vegetables. Lignans have several intriguing bioactivities, including anti-inflammatory, antioxidant, and anticancer activities. Nrf2 controls the expression of many cytoprotective genes. Activation of Nrf2 is a promising therapeutic approach for treating and preventing diseases resulting from oxidative injury and inflammation. Lignans have been demonstrated to stimulate Nrf2 signaling in a variety of in vitro and experimental animal models. The review summarizes the findings of fourteen lignans (Schisandrin A, Schisandrin B, Schisandrian C, Magnolol, Honokiol, Sesamin, Sesamol, Sauchinone, Pinoresinol, Phyllanthin, Nectandrin B, Isoeucommin A, Arctigenin, Lariciresinol) as antioxidative and anti-inflammatory agents, affirming how Nrf2 activation affects their pharmacological effects. Therefore, lignans may offer therapeutic candidates for the treatment and prevention of various diseases and may contribute to the development of effective Nrf2 modulators.
木脂素是一种广泛分布、被认可和鉴定的生物活性化合物，存在于种子、水果和蔬菜中。木脂素具有多种有趣的生物活性，包括抗炎、抗氧化和抗癌活性。Nrf2 控制着许多细胞保护基因的表达。激活 Nrf2 是治疗和预防氧化损伤和炎症引起的疾病的一种很有前途的治疗方法。木脂素已被证明可在多种体外和实验动物模型中刺激 Nrf2 信号。该综述总结了 14 种木脂素（五味子甲素、五味子乙素、五味子丙素、厚朴酚、和厚朴酚、芝麻素、芝麻林酚、蛇床子素、松脂醇、叶下珠素、Nectandrin B、异欧前胡素 A、牛蒡子苷元、紫铆因）作为抗氧化和抗炎剂的发现，证实了 Nrf2 激活如何影响它们的药理作用。因此，木脂素可能为治疗和预防各种疾病提供治疗候选物，并有助于开发有效的 Nrf2 调节剂。
