基质金属蛋白酶 1a（MMP1a）胶原酶缺乏抑制小鼠动脉粥样硬化的发生：对人类冠状动脉疾病的转化意义。
Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease.
机构信息
Center for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Interventional Cardiology, Division of Cardiology, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester (J.J.R.).
出版信息
Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):e265-e279. doi: 10.1161/ATVBAHA.120.315837. Epub 2021 Mar 25.
Abstract
[Figure: see text].
摘要
[图：见正文]。
相似文献
1
Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease.基质金属蛋白酶 1a（MMP1a）胶原酶缺乏抑制小鼠动脉粥样硬化的发生：对人类冠状动脉疾病的转化意义。
Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):e265-e279. doi: 10.1161/ATVBAHA.120.315837. Epub 2021 Mar 25.
2
Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.非经典基质金属蛋白酶 1-蛋白酶激活受体 1 信号通路促进动脉粥样硬化进展。
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1368-1380. doi: 10.1161/ATVBAHA.118.310967. Epub 2018 Apr 5.
3
Deletion of fibroblast activation protein provides atheroprotection.成纤维细胞激活蛋白缺失可提供抗动脉粥样硬化保护。
Cardiovasc Res. 2021 Mar 21;117(4):1060-1069. doi: 10.1093/cvr/cvaa142.
4
Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice.衰减弱化的超氧化物歧化酶 2 活性在高脂血症小鼠衰老过程中诱导动脉粥样硬化斑块不稳定。
J Am Heart Assoc. 2017 Oct 27;6(11):e006775. doi: 10.1161/JAHA.117.006775.
5
Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.活性氧可通过 NOX4 依赖性抑制炎症和血管重构来提供抗动脉粥样硬化作用。
Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):295-307. doi: 10.1161/ATVBAHA.115.307012. Epub 2015 Dec 29.
6
The anti-inflammatory vasostatin-2 attenuates atherosclerosis in ApoE mice and inhibits monocyte/macrophage recruitment.抗炎性血管抑制素-2可减轻载脂蛋白E基因敲除小鼠的动脉粥样硬化，并抑制单核细胞/巨噬细胞募集。
Thromb Haemost. 2017 Jan 26;117(2):401-414. doi: 10.1160/TH16-06-0475. Epub 2016 Nov 10.
7
Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1.1 型糖尿病中内皮细胞限制型内皮素-1 的过表达通过 NOX1 加重动脉粥样硬化和免疫细胞浸润。
Cardiovasc Res. 2021 Mar 21;117(4):1144-1153. doi: 10.1093/cvr/cvaa168.
8
MicroRNA-21 deficiency attenuated atherogenesis and decreased macrophage infiltration by targeting Dusp-8.miR-21 缺乏通过靶向 Dusp-8 减轻动脉粥样硬化形成并减少巨噬细胞浸润。
Atherosclerosis. 2019 Dec;291:78-86. doi: 10.1016/j.atherosclerosis.2019.10.003. Epub 2019 Oct 11.
9
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production.Rac2通过调节巨噬细胞白细胞介素-1β的产生来调控动脉粥样硬化钙化。
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):328-340. doi: 10.1161/ATVBAHA.116.308507. Epub 2016 Nov 10.
10
CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.CD200 限制动脉粥样硬化中的单核细胞生成和募集。
Circ Res. 2021 Jul 9;129(2):280-295. doi: 10.1161/CIRCRESAHA.119.316062. Epub 2021 May 12.
引用本文的文献
1
Comprehensive bioinformatics analysis uncover molecular pathways shared between osteoarthritis and atherosclerosis.全面的生物信息学分析揭示了骨关节炎和动脉粥样硬化之间共有的分子途径。
BMC Musculoskelet Disord. 2025 May 7;26(1):449. doi: 10.1186/s12891-025-08563-6.
2
Matrix Metalloproteinases: Pathophysiologic Implications and Potential Therapeutic Targets in Cardiovascular Disease.基质金属蛋白酶：心血管疾病中的病理生理意义及潜在治疗靶点
Biomolecules. 2025 Apr 17;15(4):598. doi: 10.3390/biom15040598.
3
Macrophage-based pathogenesis and theranostics of vulnerable plaques.基于巨噬细胞的易损斑块发病机制与诊疗学
Theranostics. 2025 Jan 2;15(4):1570-1588. doi: 10.7150/thno.105256. eCollection 2025.
4
Causal correlations between inflammatory proteins and heart failure: A two-sample Mendelian randomization analysis.炎症蛋白与心力衰竭之间的因果关联：一项两样本孟德尔随机化分析。
ESC Heart Fail. 2025 Apr;12(2):1374-1385. doi: 10.1002/ehf2.15151. Epub 2024 Nov 6.
5
Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis.斑块和骨髓中的神经免疫回路调节动脉粥样硬化。
Cardiovasc Res. 2025 Apr 8;120(18):2395-2407. doi: 10.1093/cvr/cvae167.
6
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders.多重蛋白质组学鉴定出与衰老及心血管代谢紊乱相关的炎症性血浆生物标志物。
Clin Proteomics. 2024 Apr 22;21(1):30. doi: 10.1186/s12014-024-09480-x.
7
Recent Advances in Anti-Atherosclerosis and Potential Therapeutic Targets for Nanomaterial-Derived Drug Formulations.纳米材料药物制剂在抗动脉粥样硬化及潜在治疗靶点方面的最新进展
Adv Sci (Weinh). 2023 Oct;10(29):e2302918. doi: 10.1002/advs.202302918. Epub 2023 Sep 12.
8
Suppression of Heart Failure With PAR1 Pepducin Technology in a Pressure Overload Model in Mice.利用 PAR1 Pepducin 技术抑制小鼠压力超负荷模型中的心力衰竭。
Circ Heart Fail. 2023 Oct;16(10):e010621. doi: 10.1161/CIRCHEARTFAILURE.123.010621. Epub 2023 Jul 21.
9
Inflammation, Microcalcification, and Increased Expression of Osteopontin Are Histological Hallmarks of Plaque Vulnerability in Patients with Advanced Carotid Artery Stenosis.炎症、微钙化和骨桥蛋白表达增加是晚期颈动脉狭窄患者斑块易损性的组织学特征。
Biomedicines. 2023 Mar 13;11(3):881. doi: 10.3390/biomedicines11030881.
10
Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading.脊柱小关节内的基质金属蛋白酶-1可诱发背根神经节和脊髓的持续性疼痛和神经元调节异常，并在拉伸负荷下改变韧带运动学。
Front Bioeng Biotechnol. 2022 Aug 3;10:926675. doi: 10.3389/fbioe.2022.926675. eCollection 2022.
本文引用的文献
1
PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study.PAR1（蛋白酶激活受体 1）肽酶诱导剂治疗在接受心脏导管检查术的冠心病和急性冠脉综合征患者中的心肌坏死：一项随机、安慰剂对照、2 期研究。
Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2990-3003. doi: 10.1161/ATVBAHA.120.315168. Epub 2020 Oct 8.
2
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.动脉粥样硬化小鼠主动脉中白细胞多样性的荟萃分析。
Circ Res. 2020 Jul 17;127(3):402-426. doi: 10.1161/CIRCRESAHA.120.316903. Epub 2020 Jul 16.
3
Matrix Metalloproteases as Influencers of the Cells' Social Media.基质金属蛋白酶作为细胞“社交媒体”的影响因子。
Int J Mol Sci. 2019 Aug 7;20(16):3847. doi: 10.3390/ijms20163847.
4
Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.非经典基质金属蛋白酶 1-蛋白酶激活受体 1 信号通路促进动脉粥样硬化进展。
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1368-1380. doi: 10.1161/ATVBAHA.118.310967. Epub 2018 Apr 5.
5
Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease.基质金属蛋白酶、血管重塑与血管疾病
Adv Pharmacol. 2018;81:241-330. doi: 10.1016/bs.apha.2017.08.002. Epub 2017 Sep 19.
6
Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association.《动物动脉粥样硬化研究的设计、实施及报告建议：美国心脏协会科学声明》
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e131-e157. doi: 10.1161/ATV.0000000000000062. Epub 2017 Jul 20.
7
Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease.针对冠心病患者PAR1的细胞穿透肽模拟物疗法
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):189-97. doi: 10.1161/ATVBAHA.115.306777.
8
Relation of baseline plasma MMP-1 levels to long-term all-cause mortality in patients with known or suspected coronary artery disease referred for coronary angiography.接受冠状动脉造影的已知或疑似冠状动脉疾病患者基线血浆基质金属蛋白酶-1水平与长期全因死亡率的关系。
Atherosclerosis. 2015 Mar;239(1):268-75. doi: 10.1016/j.atherosclerosis.2015.01.003. Epub 2015 Jan 14.
9
G-protein-coupled receptors signaling pathways in new antiplatelet drug development.新型抗血小板药物研发中的G蛋白偶联受体信号通路
Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):500-12. doi: 10.1161/ATVBAHA.114.303412. Epub 2015 Jan 29.
10
Is there new hope for therapeutic matrix metalloproteinase inhibition?治疗性基质金属蛋白酶抑制有新希望吗？
Nat Rev Drug Discov. 2014 Dec;13(12):904-27. doi: 10.1038/nrd4390. Epub 2014 Nov 7.
Zotero 插件