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降钙素原在减少外科通路抗生素使用中的作用。

The role of procalcitonin in reducing antibiotics across the surgical pathway.

机构信息

Department of Surgery, Macerata Hospital, Macerata, Italy.

Surgical Unit 1, University of Pavia, Pavia, Italy.

出版信息

World J Emerg Surg. 2021 Mar 24;16(1):15. doi: 10.1186/s13017-021-00357-0.

DOI:10.1186/s13017-021-00357-0
PMID:33761972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7988639/
Abstract

Procalcitonin (PCT) is widely considered as a highly sensitive biomarker of bacterial infection, offering general and emergency surgeons a key tool in the management of surgical infections. A multidisciplinary task force of experts met in Bologna, Italy, on April 4, 2019, to clarify the key issues in the use of PCT across the surgical pathway. The panelists presented the statements developed for each of the main questions regarding the use of PCT across the surgical pathway. An agreement on the statements was reached by the Delphi method, and this document reports the executive summary of the final recommendations approved by the expert panel.

摘要

降钙素原 (PCT) 被广泛认为是细菌感染的高度敏感生物标志物,为普通外科和急诊外科医生提供了一种管理外科感染的关键工具。一个多学科专家工作组于 2019 年 4 月 4 日在意大利博洛尼亚开会,以阐明在外科途径中使用 PCT 的关键问题。小组成员介绍了针对每个主要问题制定的关于在外科途径中使用 PCT 的陈述。通过 Delphi 方法达成了对陈述的一致意见,本文报告了专家小组批准的最终建议的执行摘要。

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World J Emerg Surg. 2021 Mar 24;16(1):15. doi: 10.1186/s13017-021-00357-0.
2
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Antibiotic Stewardship in Surgical Departments.外科科室的抗生素管理
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Front Immunol. 2023 Mar 30;14:1142346. doi: 10.3389/fimmu.2023.1142346. eCollection 2023.
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Antimicrobial Challenge in Acute Care Surgery.急性护理手术中的抗菌挑战
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本文引用的文献

1
Application value of procalcitonin, C-reactive protein and interleukin-6 in the evaluation of traumatic shock.降钙素原、C反应蛋白及白细胞介素-6在创伤性休克评估中的应用价值
Exp Ther Med. 2019 Jun;17(6):4586-4592. doi: 10.3892/etm.2019.7492. Epub 2019 Apr 16.
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Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations.急性胰腺炎的抗生素治疗:从全球过度使用到基于证据的推荐。
Pancreatology. 2019 Jun;19(4):488-499. doi: 10.1016/j.pan.2019.04.003. Epub 2019 Apr 19.
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Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials.降钙素原指导抗生素治疗对感染和脓毒症 ICU 患者临床结局的影响:随机试验的患者水平荟萃分析。
Crit Care. 2018 Aug 15;22(1):191. doi: 10.1186/s13054-018-2125-7.
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Defensive medicine in primary health care.初级卫生保健中的防御性医疗。
Scand J Prim Health Care. 2018 Sep;36(3):225-226. doi: 10.1080/02813432.2018.1499483. Epub 2018 Aug 8.
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Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis.器官衰竭和感染性坏死特征对坏死性胰腺炎死亡率的影响。
Gut. 2019 Jun;68(6):1044-1051. doi: 10.1136/gutjnl-2017-314657. Epub 2018 Jun 27.
6
Early prophylactic antibiotics for severe acute pancreatitis: A population-based cohort study using a nationwide database in Japan.重症急性胰腺炎的早期预防性抗生素治疗:一项基于日本全国数据库的人群队列研究。
J Infect Chemother. 2018 Sep;24(9):753-758. doi: 10.1016/j.jiac.2018.05.009. Epub 2018 Jun 13.
7
Procalcitonin: Usefulness in Acute Care Surgery and Trauma.降钙素原:在急性护理手术和创伤中的应用价值
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):131-136. doi: 10.1089/sur.2017.307. Epub 2018 Jan 22.
8
How is defensive medicine understood and experienced in a primary care setting? A qualitative focus group study among Danish general practitioners.在基层医疗环境中,防御性医疗是如何被理解和体验的?一项针对丹麦全科医生的定性焦点小组研究。
BMJ Open. 2017 Dec 21;7(12):e019851. doi: 10.1136/bmjopen-2017-019851.
9
Is there a role for procalcitonin in differentiating uncomplicated and complicated diverticulitis in order to reduce antibiotic therapy? A prospective diagnostic cohort study.降钙素原在鉴别单纯性和复杂性憩室炎以减少抗生素治疗方面是否有作用?一项前瞻性诊断队列研究。
Swiss Med Wkly. 2017 Nov 23;147:w14555. doi: 10.4414/smw.2017.14555. eCollection 2017.
10
Incidence of elevated procalcitonin and presepsin levels after severe trauma: a pilot cohort study.严重创伤后降钙素原和可溶性髓系细胞触发受体-1水平升高的发生率:一项前瞻性队列研究
Anaesth Intensive Care. 2017 Sep;45(5):600-604. doi: 10.1177/0310057X1704500510.