Li Yang, Chen Ling, Fang Wenge, Chen Huihong
Department of Emergency, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, P.R. China.
Department of Emergency, Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou, Fujian 363000, P.R. China.
Exp Ther Med. 2019 Jun;17(6):4586-4592. doi: 10.3892/etm.2019.7492. Epub 2019 Apr 16.
Procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) were detected to explore the value of these inflammatory markers in the assessment of traumatic shock patients. The clinical data of 80 patients with traumatic shock and infections in Zhangzhou Municipal Hospital of Fujian Province from January 2014 to December 2017 were collected as the experimental group. During the same period, 80 acute trauma patients who did not suffer from traumatic shock were regarded as the control group. According to the prognosis outcomes, the experimental group was divided into 56 patients with good prognosis and 24 patients with poor prognosis. Also the PCT, CRP and IL-6 levels in serum of patients at admission (T1), 12 h after admission (T2), three days after admission (T3) and on day 7 (T4) were detected. The differences between the three inflammatory indicators, the pre-admission injury severity score (ISS score), the acute physiology and chronic psychological score (APACHE II score) were compared between the good prognosis and the poor prognosis group. The serum CRP at the T4 time period was significantly lower than both the T1 and T2 time periods (P<0.05). There were differences in serum PCT, CRP and IL-6 between the good prognosis and the poor prognosis group at the time of T1-T4 (P<0.05). The expression levels of PCT, CRP and IL-6 in the serum of patients with poor prognosis were higher than those with good prognosis (P<0.05). Pre-admission ISS scores and APACHE II scores in patients with good prognosis were lower than those with poor prognosis (P<0.05). Detection of PCT, CRP and IL-6 expression levels in serum of the patients has an important reference value for assessing the condition of patients with traumatic shock.
检测降钙素原（PCT）、C反应蛋白（CRP）和白细胞介素-6（IL-6），以探讨这些炎症标志物在创伤性休克患者评估中的价值。收集福建省漳州市医院2014年1月至2017年12月80例创伤性休克合并感染患者的临床资料作为实验组。同期，将80例未发生创伤性休克的急性创伤患者作为对照组。根据预后结果，将实验组分为预后良好的56例患者和预后不良的24例患者。同时检测患者入院时（T1）、入院后12小时（T2）、入院后三天（T3）和第7天（T4）血清中的PCT、CRP和IL-6水平。比较预后良好组和预后不良组三种炎症指标、入院前损伤严重程度评分（ISS评分）、急性生理与慢性健康评分（APACHE II评分）之间的差异。T4时间段血清CRP明显低于T1和T2时间段（P<0.05）。T1-T4时，预后良好组和预后不良组血清PCT、CRP和IL-6存在差异（P<0.05）。预后不良患者血清中PCT、CRP和IL-6的表达水平高于预后良好患者（P<0.05）。预后良好患者入院前ISS评分和APACHE II评分低于预后不良患者（P<0.05）。检测患者血清中PCT、CRP和IL-6表达水平对评估创伤性休克患者病情具有重要参考价值。
