Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Stem Cell Res Ther. 2021 Mar 24;12(1):210. doi: 10.1186/s13287-021-02274-0.
Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood-brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders, especially in a noninvasive way. It has been shown that small molecular substances, macromolecular proteins, and even stem cells can bypass the BBB and reach the brain parenchyma following intranasal administration. Here, we review the possible brain-entry routes of transnasal treatment, the cell types, and diseases involved in intranasal stem cell therapy, and discuss its advantages and disadvantages in the treatment of central nervous system diseases, to provide a reference for the application of intranasal stem cell therapy.
干细胞的自我更新和多能性使其在治疗各种疾病方面具有巨大的潜力。然而，血脑屏障（BBB）限制了干细胞在神经疾病治疗中的应用，特别是在非侵入性方式下。已经表明，小分子物质、大分子蛋白质甚至干细胞都可以通过鼻内给药绕过 BBB 并到达脑实质。在这里，我们综述了经鼻治疗的可能的脑内进入途径、细胞类型以及鼻内干细胞治疗所涉及的疾病，并讨论了其在治疗中枢神经系统疾病方面的优缺点，为鼻内干细胞治疗的应用提供参考。
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