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一名年轻男性因 SARS-CoV-2 导致脑病和癫痫发作。

A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2.

机构信息

Pulmonary and Critical Care Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA.

Pulmonary and Critical Care Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA

出版信息

BMJ Case Rep. 2021 Mar 24;14(3):e240576. doi: 10.1136/bcr-2020-240576.

DOI:10.1136/bcr-2020-240576
PMID:33762283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7993329/
Abstract

COVID-19 has now emerged from a respiratory illness to a systemic viral illness with multisystem involvement. There is still a lot to learn about this illness as new disease associations with COVID-19 emerge consistently. We present a unique case of a neurological manifestation of a patient with structural brain disease who was COVID-19 positive and developed mental status changes, new-onset seizures and findings suggestive of viral meningitis on lumbar puncture. We also review the literature and discuss our case in the context of the other cases reported. We highlight the value of considering seizures and encephalopathy as one of the presenting features of COVID-19 disease.

摘要

COVID-19 现已从一种呼吸道疾病发展为一种全身性病毒疾病,涉及多个系统。随着与 COVID-19 不断出现的新疾病关联,我们仍有很多需要了解。我们介绍了一例结构性脑疾病患者的神经系统表现,该患者 COVID-19 检测呈阳性,出现精神状态改变、新发性癫痫发作和腰椎穿刺提示病毒性脑膜炎的发现。我们还回顾了文献,并根据报告的其他病例讨论了我们的病例。我们强调了将癫痫发作和脑病视为 COVID-19 疾病的一种表现特征的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/2f1a523dfb15/bcr-2020-240576f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/b77946074180/bcr-2020-240576f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/913c9f79f971/bcr-2020-240576f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/2f1a523dfb15/bcr-2020-240576f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/b77946074180/bcr-2020-240576f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/913c9f79f971/bcr-2020-240576f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1a/7993329/2f1a523dfb15/bcr-2020-240576f03.jpg

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本文引用的文献

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2
Acute Symptomatic Seizures in Critically Ill Patients with COVID-19: Is There an Association?急性症状性发作与 COVID-19 危重症患者:是否存在关联?
Neurocrit Care. 2021 Feb;34(1):139-143. doi: 10.1007/s12028-020-01006-1.
3
A Review of Neurological Complications of COVID-19.新型冠状病毒肺炎(COVID-19)神经系统并发症综述
Cureus. 2020 May 18;12(5):e8192. doi: 10.7759/cureus.8192.
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Seizures associated with coronavirus infections.与冠状病毒感染相关的癫痫发作。
Seizure. 2020 Jul;79:49-52. doi: 10.1016/j.seizure.2020.05.005. Epub 2020 May 11.
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COVID-19 Presenting with Seizures.表现为癫痫发作的新型冠状病毒肺炎
IDCases. 2020 May 1;20:e00782. doi: 10.1016/j.idcr.2020.e00782. eCollection 2020.
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Focal status epilepticus as unique clinical feature of COVID-19: A case report.以局灶性癫痫持续状态为独特临床表现的 COVID-19:病例报告。
Seizure. 2020 May;78:109-112. doi: 10.1016/j.seizure.2020.04.009. Epub 2020 Apr 21.
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Neurologic Features in Severe SARS-CoV-2 Infection.严重SARS-CoV-2感染的神经系统特征
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