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SARS-CoV-2 感染引发 10 岁儿童川崎病复发。

SARS-CoV-2 infection triggering recurrence of Kawasaki disease in a 10-year-old child.

机构信息

Department of Pediatrics, Holy Family Hospital, New Delhi, India.

Department of Pediatric Cardiology, Fortis Escorts Heart Institute and Research Centre, New Delhi, India.

出版信息

BMJ Case Rep. 2021 Mar 24;14(3):e240972. doi: 10.1136/bcr-2020-240972.


DOI:10.1136/bcr-2020-240972
PMID:33762287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7993297/
Abstract

SARS-CoV-2 infection has recently been related to a spectrum of hyper-inflammatory states in children. There is a striking similarity between these hyper-inflammatory states and Kawasaki disease (KD). We present an interesting case of KD recurrence in a 10-year-old child, who had previously developed KD at 4 years of age. His symptoms included fever, maculopapular rash and altered sensorium. Investigations showed noticeably elevated inflammatory markers, and an echocardiography revealed dilated coronary arteries. SARS-CoV-2 IgG antibodies were positive. The child responded dramatically to intravenous immunoglobulin and intravenous methylprednisolone. It is possible that SARS-CoV-2 infection triggered the recurrence of KD in this child who might have been genetically predisposed to KD.

摘要

SARS-CoV-2 感染与儿童一系列的过度炎症状态有关。这些过度炎症状态与川崎病(KD)之间存在显著的相似性。我们报告了一例有趣的 KD 复发病例,患儿在 4 岁时曾患 KD。他的症状包括发热、斑丘疹和意识改变。检查显示明显升高的炎症标志物,超声心动图显示冠状动脉扩张。SARS-CoV-2 IgG 抗体阳性。患儿对静脉注射免疫球蛋白和甲基强的松龙反应良好。该患儿可能存在 KD 的遗传易感性,SARS-CoV-2 感染可能触发了 KD 的复发。

相似文献

[1]
SARS-CoV-2 infection triggering recurrence of Kawasaki disease in a 10-year-old child.

BMJ Case Rep. 2021-3-24

[2]
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[6]
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[7]
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引用本文的文献

[1]
Research trends on causes of Kawasaki disease in the COVID-19 era: focus on viral infections.

Clin Exp Pediatr. 2023-1

[2]
COVID-19-related oral mucosa lesions among confirmed SARS-CoV-2 patients: a systematic review.

Int J Dermatol. 2022-1

本文引用的文献

[1]
Multisystem inflammatory syndrome in children related to COVID-19: a systematic review.

Eur J Pediatr. 2021-7

[2]
Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation.

Paediatr Respir Rev. 2021-6

[3]
COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020.

MMWR Morb Mortal Wkly Rep. 2020-8-14

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Multisystem Inflammatory Syndrome in Children and Kawasaki Disease: Two Different Illnesses with Overlapping Clinical Features.

J Pediatr. 2020-9

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Ann Rheum Dis. 2020-6-11

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Circulation. 2017-3-29

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Arch Dis Child. 2015-11

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Clin Exp Immunol. 2011-5

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