• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
SeedEZ™ Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of BioMicrosystems.SeedEZ™ 叉指电极与多功能层状生物传感器复合材料（MLBCs）：生物微系统发展中的范式转变。
J Microelectromech Syst. 2020 Oct;29(5):653-660. doi: 10.1109/jmems.2020.3003452. Epub 2020 Jun 26.
2
Makerspace microfabrication of a stainless steel 3D microneedle electrode array (3D MEA) on a glass substrate for simultaneous optical and electrical probing of electrogenic cells.在玻璃基板上通过创客空间微制造技术制备不锈钢3D微针电极阵列（3D MEA），用于对电生细胞进行同步光学和电学探测。
RSC Adv. 2020 Nov 18;10(68):41577-41587. doi: 10.1039/d0ra06070d. eCollection 2020 Nov 11.
3
Development of a Sensitive Electrochemical Enzymatic Reaction-Based Cholesterol Biosensor Using Nano-Sized Carbon Interdigitated Electrodes Decorated with Gold Nanoparticles.利用纳米尺寸的碳叉指电极上修饰的金纳米粒子，开发一种基于灵敏电化学反应的胆固醇生物传感器。
Sensors (Basel). 2017 Sep 15;17(9):2128. doi: 10.3390/s17092128.
4
Microfabricated polymer-metal biosensors for multifarious data collection from electrogenic cellular models.用于从电生细胞模型中进行多种数据收集的微加工聚合物-金属生物传感器。
Microsyst Nanoeng. 2023 Mar 1;9:22. doi: 10.1038/s41378-023-00488-1. eCollection 2023.
5
Rapid Makerspace Microfabrication and Characterization of 3D Microelectrode Arrays (3D MEAs) for Organ-on-a-Chip Models.用于芯片器官模型的3D微电极阵列（3D MEA）的快速创客空间微制造与表征
J Microelectromech Syst. 2021;30(6):853-863. doi: 10.1109/jmems.2021.3110163. Epub 2021 Sep 15.
6
Real-Time Impedance Monitoring of Epithelial Cultures with Inkjet-Printed Interdigitated-Electrode Sensors.喷墨打印叉指电极传感器实时监测上皮细胞培养物的阻抗。
Sensors (Basel). 2020 Oct 8;20(19):5711. doi: 10.3390/s20195711.
7
Simulations of Interdigitated Electrode Interactions with Gold Nanoparticles for Impedance-Based Biosensing Applications.用于基于阻抗的生物传感应用的叉指电极与金纳米粒子相互作用的模拟
Sensors (Basel). 2015 Sep 2;15(9):22192-208. doi: 10.3390/s150922192.
8
Nanoparticle-enhanced sensitivity of a nanogap-interdigitated electrode array impedimetric biosensor.纳米颗粒增强的纳米间隙叉指电极阵列阻抗生物传感器的灵敏度。
Langmuir. 2011 Nov 15;27(22):13931-9. doi: 10.1021/la202546a. Epub 2011 Oct 20.
9
Monitoring of cellular behaviour by impedance measurements on interdigitated electrode structures.通过对叉指电极结构进行阻抗测量来监测细胞行为。
Biosens Bioelectron. 1997;12(1):29-41. doi: 10.1016/0956-5663(96)89087-7.
10
Integration of cell culture and microfabrication technology.细胞培养与微制造技术的整合
Biotechnol Prog. 2003 Mar-Apr;19(2):243-53. doi: 10.1021/bp020143k.

引用本文的文献

1
Microfabricated polymer-metal biosensors for multifarious data collection from electrogenic cellular models.用于从电生细胞模型中进行多种数据收集的微加工聚合物-金属生物传感器。
Microsyst Nanoeng. 2023 Mar 1;9:22. doi: 10.1038/s41378-023-00488-1. eCollection 2023.
2
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions .一种带有可透气血红蛋白类似物的3D细胞培养器官芯片平台增强并扩展了原代人肝细胞功能。
Front Mol Biosci. 2020 Oct 19;7:568777. doi: 10.3389/fmolb.2020.568777. eCollection 2020.

本文引用的文献

1
Is It Time to Start Transitioning From 2D to 3D Cell Culture?是时候开始从二维细胞培养向三维细胞培养转变了吗？
Front Mol Biosci. 2020 Mar 6;7:33. doi: 10.3389/fmolb.2020.00033. eCollection 2020.
2
Low-Power, Multimodal Laser Micromachining of Materials for Applications in sub-5 µm Shadow Masks and sub-10 µm Interdigitated Electrodes (IDEs) Fabrication.用于制造亚5微米荫罩和亚10微米叉指电极（IDE）的低功率多模态激光材料微加工
Micromachines (Basel). 2020 Feb 8;11(2):178. doi: 10.3390/mi11020178.
3
3D Printing, Ink Casting and Micromachined Lamination (3D PICLμM): A Makerspace Approach to the Fabrication of Biological Microdevices.3D打印、油墨铸造和微机械层压（3D PICLμM）：一种用于制造生物微器件的创客空间方法。
Micromachines (Basel). 2018 Feb 15;9(2):85. doi: 10.3390/mi9020085.
4
Future challenges in the in vitro and in vivo evaluation of biomaterial biocompatibility.生物材料生物相容性的体外和体内评估中的未来挑战。
Regen Biomater. 2016 Jun;3(2):73-7. doi: 10.1093/rb/rbw001. Epub 2016 Mar 10.
5
Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.应用 xCELLigence RTCA 生物传感技术实时揭示药物反应性特征和窗口。
Biosensors (Basel). 2015 Apr 16;5(2):199-222. doi: 10.3390/bios5020199.
6
Low-pH-induced apoptosis: role of endoplasmic reticulum stress-induced calcium permeability and mitochondria-dependent signaling.低pH诱导的细胞凋亡：内质网应激诱导的钙通透性和线粒体依赖性信号传导的作用
Cell Stress Chaperones. 2015 May;20(3):431-40. doi: 10.1007/s12192-014-0568-6. Epub 2015 Apr 1.
7
Human hepatocytes as an effective alternative experimental system for the evaluation of human drug properties: general concepts and assay procedures.人肝细胞作为评估人类药物特性的有效替代实验系统：一般概念和检测程序。
ALTEX. 2008;25(1):33-42. doi: 10.14573/altex.2008.1.33.
8
Impedance characterization and modeling of electrodes for biomedical applications.生物医学应用电极的阻抗特性与建模
IEEE Trans Biomed Eng. 2005 Jul;52(7):1295-302. doi: 10.1109/TBME.2005.847523.
9
Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function.细胞水平的心脏生理学：利用培养的HL-1心肌细胞研究心肌细胞的结构与功能。
Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H823-9. doi: 10.1152/ajpheart.00986.2003.
10
HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.HL-1细胞：一种心肌细胞系，具有收缩功能并保留成年心肌细胞的表型特征。
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2979-84. doi: 10.1073/pnas.95.6.2979.

SeedEZ™ 叉指电极与多功能层状生物传感器复合材料（MLBCs）：生物微系统发展中的范式转变。

SeedEZ™ Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of BioMicrosystems.

作者信息

Didier Charles M, Kundu Avra, Shoemaker James T, Vukasinovic Jelena, Rajaraman Swaminathan

机构信息

University of Central Florida, Orlando, FL 32816, USA.

Lena Biosciences, Atlanta, GA 30332, USA.

出版信息

J Microelectromech Syst. 2020 Oct;29(5):653-660. doi: 10.1109/jmems.2020.3003452. Epub 2020 Jun 26.

DOI:10.1109/jmems.2020.3003452
PMID:33762802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7982987/
Abstract

We have developed a new technology for the realization of composite biosensor systems, capable of measuring electrical and electrophysiological signals from electrogenic cells, using SeedEZ™ 3D cell culture-scaffold material. This represents a paradigm-shift for BioMEMS processing; 'Biology-Microfabrication' versus the standard 'Microfabrication-Biology' approach. An Interdigitated Electrode (IDE) developed on the 3D cell-scaffold was used to successfully monitor acute cardiomyocyte growth and controlled population decline. We have further characterized processability of the 3D scaffold, demonstrated long-term biocompatibility of the scaffold with various cell lines and developed a multifunctional layered biosensor composites (MLBCs) using SeedEZ™ and other biocompatible substrates for future multilayer sensor integration.

摘要

我们开发了一种用于实现复合生物传感器系统的新技术，该技术能够使用SeedEZ™ 3D细胞培养支架材料测量来自电生细胞的电信号和电生理信号。这代表了生物微机电系统加工的范式转变；即“生物微制造”与标准的“微制造-生物学”方法相对。在3D细胞支架上开发的叉指电极（IDE）被用于成功监测急性心肌细胞的生长和受控的细胞数量下降。我们进一步表征了3D支架的可加工性，证明了该支架与各种细胞系的长期生物相容性，并使用SeedEZ™和其他生物相容性底物开发了多功能分层生物传感器复合材料（MLBC），用于未来的多层传感器集成。