SeedEZ™ 叉指电极与多功能层状生物传感器复合材料（MLBCs）：生物微系统发展中的范式转变。
SeedEZ™ Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of BioMicrosystems.
作者信息
Didier Charles M, Kundu Avra, Shoemaker James T, Vukasinovic Jelena, Rajaraman Swaminathan
机构信息
University of Central Florida, Orlando, FL 32816, USA.
Lena Biosciences, Atlanta, GA 30332, USA.
出版信息
J Microelectromech Syst. 2020 Oct;29(5):653-660. doi: 10.1109/jmems.2020.3003452. Epub 2020 Jun 26.
We have developed a new technology for the realization of composite biosensor systems, capable of measuring electrical and electrophysiological signals from electrogenic cells, using SeedEZ™ 3D cell culture-scaffold material. This represents a paradigm-shift for BioMEMS processing; 'Biology-Microfabrication' versus the standard 'Microfabrication-Biology' approach. An Interdigitated Electrode (IDE) developed on the 3D cell-scaffold was used to successfully monitor acute cardiomyocyte growth and controlled population decline. We have further characterized processability of the 3D scaffold, demonstrated long-term biocompatibility of the scaffold with various cell lines and developed a multifunctional layered biosensor composites (MLBCs) using SeedEZ™ and other biocompatible substrates for future multilayer sensor integration.
我们开发了一种用于实现复合生物传感器系统的新技术，该技术能够使用SeedEZ™ 3D细胞培养支架材料测量来自电生细胞的电信号和电生理信号。这代表了生物微机电系统加工的范式转变；即“生物微制造”与标准的“微制造-生物学”方法相对。在3D细胞支架上开发的叉指电极（IDE）被用于成功监测急性心肌细胞的生长和受控的细胞数量下降。我们进一步表征了3D支架的可加工性，证明了该支架与各种细胞系的长期生物相容性，并使用SeedEZ™和其他生物相容性底物开发了多功能分层生物传感器复合材料（MLBC），用于未来的多层传感器集成。
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