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How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes?

作者信息

Montero-Herradón Sara, García-Ceca Javier, Zapata Agustín G

机构信息

Department of Cell Biology, Faculty of Biology, Complutense University of Madrid, Madrid, Spain.

Health Research Institute, Hospital 12 de Octubre (imas12), Madrid, Spain.

出版信息

Front Immunol. 2021 Mar 8;12:618216. doi: 10.3389/fimmu.2021.618216. eCollection 2021.

DOI:10.3389/fimmu.2021.618216
PMID:33763065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7982454/
Abstract
摘要

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2
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Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization.EphA4 缺陷型小鼠中观察到的胸腺细胞发育改变伴随着胸腺上皮细胞和细胞外基质组织的变化。
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Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization.EphA4 缺陷型小鼠中观察到的胸腺细胞发育改变伴随着胸腺上皮细胞和细胞外基质组织的变化。
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本文引用的文献

1
Intrathymic Selection and Defects in the Thymic Epithelial Cell Development.胸腺内选择与胸腺上皮细胞发育缺陷。
Cells. 2020 Oct 2;9(10):2226. doi: 10.3390/cells9102226.
2
Rethinking Thymic Tolerance: Lessons from Mice.重新思考胸腺耐受：来自小鼠的启示。
Trends Immunol. 2019 Apr;40(4):279-291. doi: 10.1016/j.it.2019.01.011. Epub 2019 Feb 22.
3
Thymic tolerance as a key brake on autoimmunity.胸腺耐受作为自身免疫的关键制动器。
Nat Immunol. 2018 Jul;19(7):659-664. doi: 10.1038/s41590-018-0128-9. Epub 2018 Jun 20.
4
Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi.在改变的胸腺上皮中能否发生正常的T细胞发育？来自EphB缺陷胸腺的启示。
Front Endocrinol (Lausanne). 2018 Apr 3;9:135. doi: 10.3389/fendo.2018.00135. eCollection 2018.
5
Redefining thymus medulla specialization for central tolerance.重新定义胸腺髓质特化以实现中枢耐受。
J Exp Med. 2017 Nov 6;214(11):3183-3195. doi: 10.1084/jem.20171000. Epub 2017 Aug 22.
6
The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance.中枢耐受诱导过程中涉及自身免疫调节因子、微小RNA和细胞间相互作用的胸腺调控
Front Immunol. 2015 Jul 14;6:352. doi: 10.3389/fimmu.2015.00352. eCollection 2015.
7
Eph/Ephrins-Mediated Thymocyte-Thymic Epithelial Cell Interactions Control Numerous Processes of Thymus Biology.Eph/ Ephrin介导的胸腺细胞-胸腺上皮细胞相互作用控制胸腺生物学的众多过程。
Front Immunol. 2015 Jun 26;6:333. doi: 10.3389/fimmu.2015.00333. eCollection 2015.
8
Regulation of cell differentiation by Eph receptor and ephrin signaling.Eph 受体和 Ephrin 信号对细胞分化的调节。
Cell Adh Migr. 2014;8(4):339-48. doi: 10.4161/19336918.2014.970007.
9
The Eph/ephrinB signal balance determines the pattern of T-cell maturation in the thymus.Eph/ephrinB 信号平衡决定了胸腺中 T 细胞成熟的模式。
Immunol Cell Biol. 2011 Nov;89(8):844-52. doi: 10.1038/icb.2010.172. Epub 2011 Jan 18.
10
Thymic nurse cells exhibit epithelial progenitor phenotype and create unique extra-cytoplasmic membrane space for thymocyte selection.胸腺滋养细胞呈现上皮祖细胞表型，并为胸腺细胞选择创造独特的细胞外膜空间。
Cell Immunol. 2010;261(2):81-92. doi: 10.1016/j.cellimm.2009.11.004. Epub 2009 Dec 24.