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载有病毒(严重急性呼吸综合征冠状病毒2)气溶胶的热泳捕集

Thermophoretic collection of virus-laden (SARS-CoV-2) aerosols.

作者信息

Zhang A Xiangzhi, Wang B Jing, Wang C Chengbo, Lian D Zheng, Shi E Yong, Ren F Yong, Yan G Yuying

机构信息

Department of Electrical and Electronic Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.

HiFiBio (Hangzhou) Co., Ltd., Hangzhou 311215, China.

出版信息

Biomicrofluidics. 2021 Mar 12;15(2):024101. doi: 10.1063/5.0039247. eCollection 2021 Mar.

Abstract

Detecting the existence of SARS-CoV-2 in the indoor atmosphere is a practical solution to track the prevalence and prevent the spread of the virus. In this work, a thermophoretic approach is presented to collect the novel coronavirus-laden aerosols from the air and accumulate to high concentrations adequate for the sensitivity of viral RNA detection. Among the factors, the density and particle size have negligible effects on particle trajectory, while the vertical coordinates of particles increase with the rise in heating source temperature. When the heating temperature is higher than , all of the particles exit the channel from one outlet; thus, the collecting and accumulating of virus-laden aerosols can be realized. This study provides a potential approach to accelerate the detection of SARS-CoV-2 and avoid a false negative in the following RNA test.

摘要

检测室内空气中SARS-CoV-2的存在是追踪病毒流行情况和防止其传播的切实可行的解决方案。在这项工作中,提出了一种热泳方法,用于从空气中收集携带新型冠状病毒的气溶胶,并将其积累到足以满足病毒RNA检测灵敏度的高浓度。在这些因素中,密度和粒径对粒子轨迹的影响可忽略不计,但粒子的垂直坐标会随着热源温度的升高而增加。当加热温度高于 时,所有粒子都从一个出口离开通道;因此,可以实现携带病毒气溶胶的收集和积累。本研究提供了一种潜在的方法来加速SARS-CoV-2的检测,并避免在后续RNA检测中出现假阴性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407b/7955857/0cd3e0698902/BIOMGB-000015-024101_1-g001.jpg

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