Chand Dylan J, Magiri Royford B, Wilson Heather L, Mutwiri George K
Vaccinology & Immunotherapeutic Program, School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada.
Vaccine & Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, Canada.
Front Bioeng Biotechnol. 2021 Mar 4;9:625482. doi: 10.3389/fbioe.2021.625482. eCollection 2021.
Polyphosphazenes are a class of experimental adjuvants that have shown great versatility as vaccine adjuvants in many animal species ranging from laboratory rodents to large animal species. Their adjuvant activity has shown promising results with numerous viral and bacterial antigens, as well as with crude and purified antigens. Vaccines adjuvanted with polyphosphazenes can be delivered via systemic and mucosal administration including respiratory, oral, rectal, and intravaginal routes. Polyphosphazenes can be used in combination with other adjuvants, further enhancing immune responses to antigens. The mechanisms of action of polyphosphazenes have not fully been defined, but several systematic studies have suggested that they act primarily by activating innate immunity. In the present review, we will highlight progress in the development of polyphosphazenes as adjuvants in animals and their other medical applications.
聚磷腈是一类实验性佐剂，在从实验啮齿动物到大型动物等许多动物物种中，作为疫苗佐剂显示出了极大的通用性。它们的佐剂活性在众多病毒和细菌抗原以及粗制和纯化抗原方面都显示出了有前景的结果。用聚磷腈佐剂的疫苗可以通过全身和黏膜给药途径递送，包括呼吸道、口服、直肠和阴道内途径。聚磷腈可以与其他佐剂联合使用，进一步增强对抗原的免疫反应。聚磷腈的作用机制尚未完全明确，但一些系统性研究表明它们主要通过激活先天免疫起作用。在本综述中，我们将重点介绍聚磷腈作为动物佐剂的开发进展及其其他医学应用。
