Holm S, Nachemson A
Department of Orthopaedics, University of Göteborg, Sahlgren Hospital, Sweden.
Ups J Med Sci. 1988;93(1):91-9. doi: 10.1517/03009734000000042.
We have in the present experimental study investigated the influence of cigarette smoking on some nutritional parameters of the porcine intervertebral disc. The results from the acute smoking tests show a significant reduction in solute transport. Diffusion of sulphate, oxygen and methyl glucose was reduced by 30-40 per cent. This effect was obtained after exposure to smoke for 20-30 minutes. A smoking period of three hours reduced the transport efficiency to about 50 per cent. The effect of smoking decreased when the exposure ceased. The concentration gradients were close to normal after 2 hours "recovery". These findings suggest that cigarette smoking not only significantly affects the circulatory system outside the intervertebral disc, where the most pronounced effect is the reduction in solute exchange capacity, but also significantly deteriorates the cellular uptake rate and metabolite production within the disc.
在本实验研究中，我们调查了吸烟对猪椎间盘某些营养参数的影响。急性吸烟试验结果显示溶质转运显著降低。硫酸盐、氧气和甲基葡萄糖的扩散减少了30% - 40%。暴露于烟雾20 - 30分钟后出现这种效应。三小时的吸烟期使转运效率降低至约50%。停止暴露后，吸烟的影响减弱。“恢复”2小时后浓度梯度接近正常。这些发现表明，吸烟不仅显著影响椎间盘外的循环系统，其中最明显的影响是溶质交换能力降低，而且还显著恶化椎间盘内的细胞摄取率和代谢产物生成。
