Teng Kaixuan, An Qi, Chen Yao, Zhang Yihe, Zhao Yantao
Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Sciences and Technology, China University of Geosciences, Beijing 100083, China.
Institute of Orthopedics, Fourth Medical Center of the General Hospital of CPLA, Beijing 100048, China.
ACS Biomater Sci Eng. 2021 Apr 12;7(4):1302-1337. doi: 10.1021/acsbiomaterials.1c00116. Epub 2021 Mar 25.
Alginate is a natural polysaccharide that is easily chemically modified or compounded with other components for various types of functionalities. The alginate derivatives are appealing not only because they are biocompatible so that they can be used in biomedicine or tissue engineering but also because of the prospering bioelectronics that require various biomaterials to interface between human tissues and electronics or to serve as electronic components themselves. The study of alginate-based materials, especially hydrogels, have repeatedly found new frontiers over recent years. In this Review, we document the basic properties of alginate, their chemical modification strategies, and the recent development of alginate-based functional composite materials. The newly thrived functions such as ionically conductive hydrogel or 3D or 4D cell culturing matrix are emphasized among other appealing potential applications. We expect that the documentation of relevant information will stimulate scientific efforts to further develop biocompatible electronics or smart materials and to help the research domain better address the medicine, energy, and environmental challenges faced by human societies.
藻酸盐是一种天然多糖，易于进行化学修饰或与其他成分复合以实现各种功能。藻酸盐衍生物之所以具有吸引力，不仅是因为它们具有生物相容性，可用于生物医学或组织工程，还因为蓬勃发展的生物电子学需要各种生物材料在人体组织和电子设备之间起界面作用，或者本身作为电子元件。近年来，对基于藻酸盐的材料，尤其是水凝胶的研究不断开拓新领域。在本综述中，我们记录了藻酸盐的基本特性、它们的化学修饰策略以及基于藻酸盐的功能复合材料的最新进展。除其他有吸引力的潜在应用外，还重点介绍了新出现的功能，如离子导电水凝胶或3D或4D细胞培养基质。我们期望相关信息的记录将激发科学努力，以进一步开发生物相容性电子器件或智能材料，并帮助该研究领域更好地应对人类社会面临的医学、能源和环境挑战。
