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利用海藻酸钠-壳聚糖凝胶混合物控制脱落酸(ABA)的释放:一种增强小分子递送控制剂的协同方法。

The Controlled Release of Abscisic Acid (ABA) Utilizing Alginate-Chitosan Gel Blends: A Synergistic Approach for an Enhanced Small-Molecule Delivery Controller.

作者信息

Valdes Oscar, Bustos Daniel, Guzmán Luis, Muñoz-Vera Marcelo, Urra Gabriela, Castro Ricardo I, Morales-Quintana Luis

机构信息

Centro de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca 3460000, Chile.

Laboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.

出版信息

Gels. 2024 Mar 8;10(3):185. doi: 10.3390/gels10030185.

Abstract

The integration of abscisic acid (ABA) into a chitosan-alginate gel blend unveils crucial insights into the formation and stability of these two substances. ABA, a key phytohormone in plant growth and stress responses, is strategically targeted for controlled release within these complexes. This study investigates the design and characterization of this novel controlled-release system, showcasing the potential of alginate-chitosan gel blends in ABA delivery. Computational methods, including molecular dynamics simulations, are employed to analyze the structural effects of microencapsulation, offering valuable insights into complex behavior under varying conditions. This paper focuses on the controlled release of ABA from these complexes, highlighting its strategic importance in drug delivery systems and beyond. This controlled release enables targeted and regulated ABA delivery, with far-reaching implications for pharmaceuticals, agriculture, and plant stress response studies. While acknowledging context dependency, the paper suggests that the liberation or controlled release of ABA holds promise in applications, urging further research and experimentation to validate its utility across diverse fields. Overall, this work significantly contributes to understanding the characteristics and potential applications of chitosan-alginate complexes, marking a noteworthy advancement in the field of controlled-release systems.

摘要

将脱落酸(ABA)整合到壳聚糖-海藻酸盐凝胶混合物中,揭示了这两种物质形成和稳定性的关键见解。ABA是植物生长和应激反应中的一种关键植物激素,在这些复合物中被策略性地用于控制释放。本研究调查了这种新型控释系统的设计和特性,展示了海藻酸盐-壳聚糖凝胶混合物在ABA递送方面的潜力。采用包括分子动力学模拟在内的计算方法来分析微囊化的结构效应,为不同条件下的复杂行为提供有价值的见解。本文重点关注ABA从这些复合物中的控释,强调其在药物递送系统及其他领域的战略重要性。这种控释能够实现有针对性和可控的ABA递送,对制药、农业和植物应激反应研究具有深远影响。在承认上下文依赖性的同时,本文表明ABA的释放或控释在应用中具有前景,敦促进一步研究和实验以验证其在不同领域的效用。总体而言,这项工作对理解壳聚糖-海藻酸盐复合物的特性和潜在应用做出了重大贡献,标志着控释系统领域的一项显著进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b6/10970481/137b3a741249/gels-10-00185-g001.jpg

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