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一过性妊娠期高血压和子痫前期:两例病例报告及严格监测必要性的文献复习

Transient gestational hypertension and pre-eclampsia: Two case reports and literature review on the need for stringent monitoring.

机构信息

Department of Obstetrics and Gynaecology, Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa; and, Department of Obstetrics and Gynaecology, Leratong Hospital, Krugersdorp.

出版信息

S Afr Fam Pract (2004). 2021 Mar 16;63(1):e1-e6. doi: 10.4102/safp.v63i1.5236.

Abstract

Transient gestation hypertension is a contributor to adverse pregnancy outcomes particularly when it progresses to pre-eclampsia (PE). This requires frequent monitoring. We illustrate the need for stringent monitoring of gestational hypertension, transient gestational hypertension (TGH) and PE without severe features and conducted a brief rapid review of the literature. Two cases are presented: Firstly, a 25-year-old primigravida at 30 gestational weeks who had an isolated TGH with high blood pressure (BP) of 141/87 mmHg, which was not investigated. Four weeks later, she presented with a BP of 202/128 mmHg, imminent eclampsia and intrauterine foetal death and had an uncomplicated induction of labour and delivered a 1400 g macerated male stillborn. Secondly, a 30-year-old primigravida at 30 gestational weeks who developed PE but her monitoring was compromised initially by inadequate healthcare capacity including unavailability of hospital bed-space for inpatient care and later by poor clinic attendance as a result of poor finances. At 32 gestational weeks, she presented with decreased foetal movement and was diagnosed as haemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome and intrauterine foetal death. She was stabilised, had induction of labour and delivered a 1400 g male macerated stillborn. Thereafter, the need for her to go home to complete the cultural burial rites of her baby and the pressure from her workplace resulted in an inadequate postpartum follow-up care. In conclusion, transient gestational hypertension is associated with adverse maternal and foetal outcomes, including foetal demise. Unavailability of hospital bed-space and poor personal finances interfere with stringent monitoring of hypertensive disorders and can be associated with adverse pregnancy outcomes. Stringent laboratory monitoring in these cases is defined by the authors as testing at least blood levels of serum Creatinine, Haemoglobin concentration, Alanine transaminase and Platelet count (abbreviated as 'CHAP') weekly.

摘要

短暂性妊娠高血压是不良妊娠结局的一个因素,尤其是当它进展为子痫前期(PE)时。这需要频繁监测。我们说明了严格监测妊娠高血压、短暂性妊娠高血压(TGH)和无严重特征的 PE 的必要性,并对文献进行了简要快速回顾。呈现了两个案例:首先,一位 25 岁的初产妇在 30 孕周时出现孤立性 TGH,血压为 141/87mmHg,未进行调查。四周后,她出现血压为 202/128mmHg,即将发生子痫和宫内胎儿死亡,并进行了简单的引产,产下了一名 1400 克的男性死产儿。其次,一位 30 岁的初产妇在 30 孕周时发生了 PE,但她的监测最初受到医疗保健能力不足的影响,包括无法获得住院治疗的床位,以及后来因财务状况不佳而导致的就诊率低。在 32 孕周时,她出现胎儿运动减少,并被诊断为溶血性肝酶升高、血小板计数降低(HELLP)综合征和宫内胎儿死亡。她得到了稳定,进行了引产,产下了一名 1400 克的男性死产儿。此后,她需要回家完成婴儿的文化葬礼仪式,并且来自工作场所的压力导致产后随访护理不足。总之,短暂性妊娠高血压与不良的母婴结局相关,包括胎儿死亡。床位不足和个人财务状况不佳会干扰对高血压疾病的严格监测,并可能导致不良的妊娠结局。在这些情况下,作者定义的严格实验室监测是指每周至少检查血清肌酐、血红蛋白浓度、丙氨酸转氨酶和血小板计数的血液水平(缩写为“CHAP”)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0738/8377990/8c169dfb9a51/SAFP-63-5236-g001.jpg

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