Kanaev S V, Kolygin B A, Malinin A P, Chikrizov S I
Med Radiol (Mosk). 1987 May;32(5):13-5.
Five-year therapeutic results were studied in 47 patients aged 2 to 14 to elucidate the role of radiotherapy in the treatment of stage IIIB Hodgkin's disease. 23 patients received combined chemotherapy after MOPP and COPP schemes; 24 patients received chemoradiotherapy including all lesions detected before treatment (12 persons) or the so called "manifesting" areas (the rest of 12 patients) in the zone of radiation exposure. Combined chemotherapy was shown to be not the only method of specific treatment as the resultant complete remission was achieved only in 15 (65.2%) out of 23 patients. The 5-year survival rate was 72%; a recurrence-free course was noted in 52.2% of the patients in complete remission. A complete remission was achieved in all 24 patients on chemoradiotherapy. The 5-year survival rate was 94.3%, a recurrence-free course was noted in 63.9% of the patients. Slightly better, though statistically insignificant results due to a small number of patients in the groups were achieved in irradiation of all zones of lesions detected before treatment (the 5-year survival rate was 100%, a recurrence-free course 72.7%) as opposed to those in irradiation of the "manifesting" zones only (84.6 and 54.8% respectively). A conclusion was made of the importance of irradiation in the treatment of stage IIIB Hodgkin's disease in children raising 5-year survival rates.
对47例年龄在2至14岁的患者进行了为期五年的治疗结果研究，以阐明放射治疗在IIIB期霍奇金病治疗中的作用。23例患者按照MOPP和COPP方案接受联合化疗；24例患者接受放化疗，包括治疗前检测到的所有病灶（12人）或放射暴露区域内所谓的“明显”区域（其余12例患者）。联合化疗并非唯一的特异性治疗方法，因为23例患者中只有15例（65.2%）实现了完全缓解。5年生存率为72%；完全缓解的患者中有52.2%记录为无复发病程。24例接受放化疗的患者均实现了完全缓解。5年生存率为94.3%，患者中有63.9%记录为无复发病程。与仅照射“明显”区域（分别为84.6%和54.8%）相比，照射治疗前检测到的所有病灶区域（5年生存率为100%，无复发病程为72.7%）取得了略好的结果，尽管由于组内患者数量少，结果在统计学上无显著差异。得出结论，放射治疗对提高儿童IIIB期霍奇金病的5年生存率具有重要意义。
