Centre for Materials Science, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia.
School of Chemistry and Physics, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia.
Biomacromolecules. 2021 Apr 12;22(4):1590-1599. doi: 10.1021/acs.biomac.1c00046. Epub 2021 Mar 25.
A rapid photo-curing system based on poly(2-ethyl-2-oxazoline--2-allylamidopropyl-2-oxazoline) and its compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) and the methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (CMestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained by a simple water-in-oil gelation method using thiol-ene coupling and investigated the biocompatibility of these hydrogel spheres in a 28-day murine subdermal model. For comparison, hydrogel spheres prepared from poly(ethylene glycol) were also implanted. Both materials displayed mild, yet typical foreign body responses with little signs of fibrosis. This is the first report on the foreign body response of a poly(2-oxazoline) hydrogel, which paves the way for future investigations into how this highly tailorable class of materials can be used for implantable hydrogel devices.
提出了一种基于聚（2-乙基-2-恶唑啉-2-丙烯酰胺丙基-2-恶唑啉）的快速光固化体系及其相容性。该基础聚合物是通过 2-乙基-2-恶唑啉（EtOx）和含有 2-甲氧羰丙基-2-恶唑啉甲酯（CMestOx）的共聚合反应合成的，然后与丙烯酰胺反应得到高度水溶性的大分子单体。我们展示了可以通过简单的水包油凝胶化方法，使用硫醇-烯键加成反应得到球形水凝胶，并在 28 天的小鼠皮下模型中研究了这些水凝胶球的生物相容性。为了进行比较，还植入了由聚乙二醇制备的水凝胶球。这两种材料都表现出温和但典型的异物反应，几乎没有纤维化的迹象。这是首次报道聚（2-恶唑啉）水凝胶的异物反应，为进一步研究如何将这类高度可定制的材料用于可植入水凝胶装置铺平了道路。
