Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia.
Macromol Rapid Commun. 2012 Oct 15;33(19):1695-700. doi: 10.1002/marc.201200249. Epub 2012 Aug 7.
Copoly(2-oxazoline)s, prepared by the cationic ring-opening polymerization of 2-(dec-9-enyl)-2-oxazoline with either 2-methyl-2-oxazoline or 2-ethyl-2-oxazoline, are crosslinked with small dithiol molecules under UV irradiation to form homogeneous networks. In situ monitoring of the crosslinking reaction by photo-rheology reveals the formation of soft gels within minutes. The degree of swelling in water is tunable based on the hydrophilicity of the starting macromers and the proportion of alkene side arms present. Furthermore, degradable hydrogels are prepared based on incorporation of a hydrolytically cleavable dithiol crosslinker. The rapid synthesis of the macromers and mild crosslinking conditions make these materials ideal for future biomaterial applications.
聚（2-恶唑啉）是通过 2-（癸-9-烯基）-2-恶唑啉与 2-甲基-2-恶唑啉或 2-乙基-2-恶唑啉的阳离子开环聚合制备的，可在紫外光照射下与小分子二硫醇交联，形成均相网络。用光流变学原位监测交联反应表明，几分钟内即可形成软凝胶。根据起始大分子单体的亲水性和烯侧臂的比例，可调节在水中的溶胀度。此外，还基于掺入可水解的二硫键交联剂制备了可降解水凝胶。大分子单体的快速合成和温和的交联条件使这些材料成为未来生物材料应用的理想选择。
