Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Expert Rev Anticancer Ther. 2021 Jul;21(7):795-803. doi: 10.1080/14737140.2021.1908132. Epub 2021 Apr 7.
Abnormal BUB1B expression has been proven to be related to the poor prognosis of various tumors. This meta-analysis aimed to identify the prognostic role of BUB1B in patients with lung adenocarcinoma (LUAD).
Relevant studies from the PubMed, Embase, Web of Science, and Cochrane Library databases and two public databases that stored sequencing data were retrieved. The standardized mean difference (SMD) and 95% confidence intervals (CIs) for the association between the BUB1B expression level and clinical characteristics were calculated. Pooled hazard ratios (HRs) and 95% CIs were calculated to estimate the association between BUB1B expression and survival outcomes.
A total of 16 studies involving 2771 LUAD patients with BUB1B expression were included in this meta-analysis. Patients with older age showed low BUB1B expression. High BUB1B expression was associated with male sex, a smoking history, and an advanced TNM stage. High BUB1B expression was predictive of poor overall survival (OS) and progression-free survival (PFS). In addition, no publication bias was found.
This meta-analysis demonstrates that BUB1B is a significant biomarker for a poor prognosis and poor clinicopathological outcomes in patients with LUAD.
异常的 BUB1B 表达已被证明与各种肿瘤的预后不良有关。本荟萃分析旨在确定 BUB1B 在肺腺癌（LUAD）患者中的预后作用。
从 PubMed、Embase、Web of Science 和 Cochrane Library 数据库以及两个存储测序数据的公共数据库中检索相关研究。计算 BUB1B 表达水平与临床特征之间关联的标准化均数差（SMD）和 95%置信区间（CI）。计算合并危险比（HR）和 95%CI 以估计 BUB1B 表达与生存结局之间的关联。
共有 16 项研究纳入了 2771 例具有 BUB1B 表达的 LUAD 患者，进行了这项荟萃分析。年龄较大的患者 BUB1B 表达水平较低。高 BUB1B 表达与男性、吸烟史和晚期 TNM 分期相关。高 BUB1B 表达预示着总体生存率（OS）和无进展生存率（PFS）较差。此外，未发现发表偏倚。
本荟萃分析表明，BUB1B 是 LUAD 患者预后不良和不良临床病理结局的重要生物标志物。
