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少年被罗素蝰蛇咬伤后发生阴茎异常勃起:一个不寻常的病例报告。

Priapism following a juvenile Russell's viper bite: An unusual case report.

机构信息

Manian Medical Centre, Erode, Tamil Nadu, India.

Toxiven Biotech Private Limited, Coimbatore, Tamil Nadu, India.

出版信息

PLoS Negl Trop Dis. 2021 Mar 25;15(3):e0009242. doi: 10.1371/journal.pntd.0009242. eCollection 2021 Mar.

Abstract

Following a bite from a juvenile Russell's viper (Daboia russelii), a priapism (painful erection) developed rapidly in a 16-year-old male and only subsided after administration of antivenom 3 hours later. Potential mechanisms for this snakebite-induced priapism are unclear but likely due to venom toxins causing nitric oxide (NO) release and subsequent vasodilation of endothelium in the corpus cavernosum, although the possible involvement of other mechanisms cannot be ruled out. We strongly believe that this unusual case report may lead to further scientific research in order to improve the clinical understanding of the pathophysiology of envenomation due to Russell's viper bites. Although it is too early to speculate, further research may also discover the possibilities of developing venom-based candidate molecules to treat sexual dysfunction in males and females.

摘要

被幼年的圆斑蝰(Daboia russelii)咬伤后,一名 16 岁男性迅速出现阴茎异常勃起(疼痛性勃起),仅在 3 小时后给予抗蛇毒血清后才缓解。这种蛇咬伤引起的阴茎异常勃起的潜在机制尚不清楚,但可能是由于毒液毒素引起一氧化氮(NO)释放,随后导致海绵体中的内皮细胞舒张,尽管不能排除其他机制的可能。我们坚信,这种不寻常的病例报告可能会促使进一步的科学研究,以提高对因圆斑蝰咬伤导致的毒液中毒的病理生理学的临床认识。虽然现在推测还为时过早,但进一步的研究也可能发现基于毒液的候选分子治疗男性和女性性功能障碍的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ff7/7993604/8f5a3d693331/pntd.0009242.g001.jpg

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