Herrmann W, Hanf S, Schütz C, Lindhofer H G, Schmidt H, Strauss H J, Schaedel H, Oswald B
Bezirkskrankenhauses Meiningen, Zentralklinik für Herz- Lungenkrankheiten, Bad Berka.
Z Gesamte Inn Med. 1988 Feb 15;43(4):86-92.
In 242 coronarographed male patients (51.7 +/- 7.6 years) with 0-, 1-, 2- or 3-vessel diseases as well as a clinically healthy control group (n = 68, 50.6 +/- 8.5 years) the lipoprotein pattern was investigated: total-, LDL-, HDL-, HDL2-, HDL3-, beta-, pre-beta-alpha-cholesterol, triglycerides, apolipoproteins (Apo) A-I, A-II, B, (A-I)HDL, Lp(a). With regard to the separation of patients with diseases of the coronary vessels and healthy persons out of the individual parameters Apo A-I (turbidimetrically), HDL3 and HDL cholesterol had the greatest significance (maximal diagnostic efficiency: 0.81, 0.76, 0.72). For the assessment of the severity of the change of the coronary vessels the quotient total/HDL cholesterol was most suitable (efficiency: 0.67). Differences in the diagnostic significance were established in the determination of a parameter by means of different methods. The intake of beta-receptor blockers increased the concentration of the triglycerides and pre-beta-cholesterol.
在242例接受冠状动脉造影的男性患者（年龄51.7±7.6岁）中，患有单支、双支、三支血管病变以及一个临床健康对照组（n = 68，年龄50.6±8.5岁），对其脂蛋白模式进行了研究：总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、高密度脂蛋白2胆固醇、高密度脂蛋白3胆固醇、β-胆固醇、前β-胆固醇、α-胆固醇、甘油三酯、载脂蛋白（Apo）A-I、A-II、B、（A-I）HDL、脂蛋白（a）。就从各个参数中区分出冠状动脉血管疾病患者和健康人而言，载脂蛋白A-I（比浊法）、高密度脂蛋白3和高密度脂蛋白胆固醇具有最大意义（最大诊断效率：0.81、0.76、0.72）。对于评估冠状动脉血管病变的严重程度，总胆固醇/高密度脂蛋白胆固醇的比值最为合适（效率：0.67）。通过不同方法测定参数时，诊断意义存在差异。服用β受体阻滞剂会增加甘油三酯和前β-胆固醇的浓度。
