Department of Clinical Pharmacy, Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center and Cardiovascular Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Daneshgah St., Tabriz, Iran.
High Blood Press Cardiovasc Prev. 2021 May;28(3):283-290. doi: 10.1007/s40292-021-00445-x. Epub 2021 Mar 25.
Data has shown that pharmacist-directed health services play a key role in the treatment of hypertension.
We aimed to perform this study to compare two methods of the pharmacist-directed home blood pressure monitoring (HBPM) and the usual care.
A total of 126 patients with uncontrolled blood pressure (BP) were randomized 1:1 into the pharmacist-directed HBPM and the usual care groups. In the intervention group, the patients were trained to measure their BPs and adjust their medications based on the designed protocol under the supervision of a clinical pharmacist. The primary endpoint of the study was the comparison of the BPs at baseline and months 1, 3, and 6.
One month after the allocation, the baseline systolic BP (SBP) (150.5 ± 13.1 vs. 149.7 ± 11.2 mm Hg; P = 0.71) and diastolic BP (DBP) (97.2 ± 9.8 vs. 93.6 ± 14.5; P = 0.11) significantly dropped to the control range equally in 85.2% of the patients in two groups (SBP: 128.8 ± 6.4 vs. 125.6 ± 7.1 mm Hg; P = 0.01 and DBP: 89.1 ± 6.2 vs. 81.5 ± 6.0 mm Hg; P = 0.01). This pattern continued during the study period (month 6; SBP: 115.6 ± 10.1vs. 116.1 ± 9.6 mm Hg; P = 0.78; DBP: 79.0 ± 5.0 vs. 77.2 ± 5.8 mm Hg; P = 0.08).
In this study, we did not observe any significant difference between the pharmacist-directed HBPM and usual care methods in decreasing BP.
数据表明，药剂师主导的健康服务在高血压治疗中发挥着关键作用。
我们旨在进行这项研究，比较两种由药剂师主导的家庭血压监测（HBPM）和常规护理方法。
共有 126 名血压控制不佳的患者被随机分为 1:1 的药剂师主导的 HBPM 组和常规护理组。在干预组中，患者在临床药师的监督下，根据设计的方案接受培训，测量血压并调整药物。研究的主要终点是比较基线和第 1、3、6 个月的血压。
分配后 1 个月，两组患者的基线收缩压（SBP）（150.5±13.1 与 149.7±11.2 mm Hg；P=0.71）和舒张压（DBP）（97.2±9.8 与 93.6±14.5 mm Hg；P=0.11）均显著下降至正常范围，两组患者各有 85.2%（SBP：128.8±6.4 与 125.6±7.1 mm Hg；P=0.01 和 DBP：89.1±6.2 与 81.5±6.0 mm Hg；P=0.01）。这种模式在研究期间（第 6 个月）持续存在（SBP：115.6±10.1 与 116.1±9.6 mm Hg；P=0.78；DBP：79.0±5.0 与 77.2±5.8 mm Hg；P=0.08）。
在这项研究中，我们没有观察到由药剂师主导的 HBPM 和常规护理方法在降低血压方面有任何显著差异。
