Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Department of Oral Health and Clinical Science, Tokyo Dental College, Tokyo, Japan.
Mol Pain. 2021 Jan-Dec;17:17448069211002009. doi: 10.1177/17448069211002009.
Pain sensitivity differs individually, but the mechanisms and genetic factors that underlie these differences are not fully understood. To investigate genetic factors that are involved in sensing cold pain, we applied a cold-induced pain test and evaluated protease-activated receptor 2 (PAR2/F2RL1) and transient receptor potential melastatin 8 (TRPM8), which are related to pain. We statistically investigated the associations between genetic polymorphisms and cold pain sensitivity in 461 healthy patients who were scheduled to undergo cosmetic orthognathic surgery for mandibular prognathism. We found an association between cold pain sensitivity and the rs2243057 polymorphism of the gene. We also found a significant association between cold pain sensitivity and the rs12992084 polymorphism of the gene. Carriers of the minor A allele of the rs2243057 polymorphism of and minor C allele of the rs12992084 polymorphism of exhibited a longer latency to pain perception in the cold-induced pain test, reflecting a decrease in cold pain sensitivity. These results suggest that genetic polymorphisms of both and are involved in individual differences in cold pain sensitivity.
疼痛敏感性因人而异，但这些差异的机制和遗传因素尚未完全阐明。为了研究与冷痛感知相关的遗传因素，我们应用冷诱导疼痛测试评估了蛋白酶激活受体 2（PAR2/F2RL1）和瞬时受体电位 melastatin 8（TRPM8），这两种物质与疼痛有关。我们对 461 名拟行下颌前突整形术的健康患者的遗传多态性与冷痛敏感性之间的相关性进行了统计学研究。我们发现基因 rs2243057 多态性与冷痛敏感性之间存在关联。我们还发现基因 rs12992084 多态性与冷痛敏感性之间存在显著关联。携带基因 rs2243057 的 minor A 等位基因和基因 rs12992084 的 minor C 等位基因的个体在冷诱导疼痛测试中对疼痛的感知潜伏期较长，反映出冷痛敏感性降低。这些结果表明，和基因的遗传多态性都参与了冷痛敏感性的个体差异。
