• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

磷脂和 G 蛋白偶联受体对冷敏感瞬时受体电位通道 TRPM8 的调节。

Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G-coupled receptors.

机构信息

Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA.

出版信息

Channels (Austin). 2020 Dec;14(1):79-86. doi: 10.1080/19336950.2020.1734266.

DOI:10.1080/19336950.2020.1734266
PMID:32101066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7153793/
Abstract

The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P]. This review discusses recent findings on the role of PI(4,5)P and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P in Ca dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.

摘要

瞬时受体电位 melastatin 8（TRPM8）离子通道是环境冷温度的重要传感器。该通道的冷和薄荷醇诱导激活需要膜磷脂磷脂酰肌醇 4,5-二磷酸[PI（4,5）P]的存在。本综述讨论了 PI（4,5）P 和 G 蛋白在受体激活时对 TRPM8 调节中的作用的最新发现。我们还将总结 PI（4,5）P 在 Ca 依赖性 TRPM8 活性脱敏/适应中的作用的知识，以及最近在这种脂质与 TRPM8 结合的结构基础方面的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/b601eceb27b8/kchl-14-01-1734266-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/3c11fad963e7/kchl-14-01-1734266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/0f80d6ee713c/kchl-14-01-1734266-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/14ea144cd6ba/kchl-14-01-1734266-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/b601eceb27b8/kchl-14-01-1734266-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/3c11fad963e7/kchl-14-01-1734266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/0f80d6ee713c/kchl-14-01-1734266-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/14ea144cd6ba/kchl-14-01-1734266-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/7153793/b601eceb27b8/kchl-14-01-1734266-g004.jpg

相似文献

1
Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G-coupled receptors.磷脂和 G 蛋白偶联受体对冷敏感瞬时受体电位通道 TRPM8 的调节。
Channels (Austin). 2020 Dec;14(1):79-86. doi: 10.1080/19336950.2020.1734266.
2
Sensitizes TRPM8 to Inhibition by PI(4,5)P Depletion upon Receptor Activation.使 TRPM8 在受体激活时对 PI(4,5)P 耗竭的抑制作用敏感。
J Neurosci. 2019 Jul 31;39(31):6067-6080. doi: 10.1523/JNEUROSCI.2304-18.2019. Epub 2019 May 24.
3
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers.平面脂双层中冷和化学激动剂激活的瞬时受体电位 melastatin 8（TRPM8）通道的门控。
J Neurosci. 2010 Sep 15;30(37):12526-34. doi: 10.1523/JNEUROSCI.3189-10.2010.
4
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate.神经元冷感受器TRPM8的活性由磷脂酶C通过磷脂磷酸肌醇4,5-二磷酸进行调节。
J Biol Chem. 2009 Jan 16;284(3):1570-82. doi: 10.1074/jbc.M807270200. Epub 2008 Nov 18.
5
Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives.异冰片抑制TRPM8的作用不同于薄荷醇和薄荷醇衍生物诱导的脱敏作用。
J Biol Chem. 2009 Feb 13;284(7):4102-11. doi: 10.1074/jbc.M806651200. Epub 2008 Dec 18.
6
Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8.薄荷醇受体 TRPM8 对配体和脂质识别的当前观点。
Trends Biochem Sci. 2020 Sep;45(9):806-819. doi: 10.1016/j.tibs.2020.05.008. Epub 2020 Jun 9.
7
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.冷激活瞬时受体电位通道 TRPM8 对冷却剂和脂质的感应结构基础。
Science. 2019 Mar 1;363(6430). doi: 10.1126/science.aav9334. Epub 2019 Feb 7.
8
Regulation of TRPM8 channel activity.TRPM8 通道活性的调节。
Mol Cell Endocrinol. 2012 Apr 28;353(1-2):68-74. doi: 10.1016/j.mce.2011.10.023. Epub 2011 Oct 28.
9
Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels.磷脂酰肌醇 4,5-二磷酸水平的降低介导冷传感器 TRPM8 通道的脱敏。
J Physiol. 2011 Dec 15;589(Pt 24):6007-27. doi: 10.1113/jphysiol.2011.220228. Epub 2011 Oct 17.
10
Structures of a mammalian TRPM8 in closed state.哺乳动物 TRPM8 处于关闭状态的结构。
Nat Commun. 2022 Jun 3;13(1):3113. doi: 10.1038/s41467-022-30919-y.

引用本文的文献

1
Chemogenomic Screening in a Patient-Derived 3D Fatty Liver Disease Model Reveals the CHRM1-TRPM8 Axis as a Novel Module for Targeted Intervention.在患者来源的3D脂肪肝疾病模型中的化学基因组筛选揭示了CHRM1-TRPM8轴作为靶向干预的新模块。
Adv Sci (Weinh). 2025 Jan;12(3):e2407572. doi: 10.1002/advs.202407572. Epub 2024 Nov 28.
2
Navigating the Controversies: Role of TRPM Channels in Pain States.探索争议：TRPM 通道在疼痛状态中的作用。
Int J Mol Sci. 2024 Sep 24;25(19):10284. doi: 10.3390/ijms251910284.
3
QTL mapping and identification of candidate genes for cold tolerance at the germination stage in wild rice.

本文引用的文献

1
Direct Gα Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation.缓激肽受体激活引起的瞬时受体电位阳离子通道亚家族 M 成员 8（TRPM8）抑制的唯一机制是直接 Gα 门控。
Cell Rep. 2019 Jun 18;27(12):3672-3683.e4. doi: 10.1016/j.celrep.2019.05.080.
2
Sensitizes TRPM8 to Inhibition by PI(4,5)P Depletion upon Receptor Activation.使 TRPM8 在受体激活时对 PI(4,5)P 耗竭的抑制作用敏感。
J Neurosci. 2019 Jul 31;39(31):6067-6080. doi: 10.1523/JNEUROSCI.2304-18.2019. Epub 2019 May 24.
3
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
野生稻萌发期耐冷性 QTL 定位与候选基因鉴定
Genes Genomics. 2023 Jul;45(7):867-885. doi: 10.1007/s13258-023-01394-6. Epub 2023 May 20.
4
On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications.关于瞬时受体电位 melastatin 通道的调控：当前观点及抗癌治疗意义
Front Oncol. 2023 Feb 9;12:1065935. doi: 10.3389/fonc.2022.1065935. eCollection 2022.
5
What structures did, and did not, reveal about the function of the epithelial Ca channels TRPV5 and TRPV6.这些结构揭示了上皮钙通道 TRPV5 和 TRPV6 的哪些功能，又没有揭示哪些功能。
Cell Calcium. 2022 Sep;106:102620. doi: 10.1016/j.ceca.2022.102620. Epub 2022 Jul 3.
6
The cation channel TRPM8 influences the differentiation and function of human monocytes.阳离子通道 TRPM8 影响人单核细胞的分化和功能。
J Leukoc Biol. 2022 Sep;112(3):365-381. doi: 10.1002/JLB.1HI0421-181R. Epub 2022 Mar 1.
7
Anti-Hyperalgesic Properties of Menthol and Pulegone.薄荷醇和胡薄荷酮的抗痛觉过敏特性。
Front Pharmacol. 2021 Nov 30;12:753873. doi: 10.3389/fphar.2021.753873. eCollection 2021.
8
TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.TRPM8 通道：结构研究和药物调节的进展。
Int J Mol Sci. 2021 Aug 7;22(16):8502. doi: 10.3390/ijms22168502.
9
RNA-Seq reveals divergent gene expression between larvae with contrasting trophic modes in the poecilogonous polychaete Boccardia wellingtonensis.RNA-Seq 揭示了具有不同取食方式的幼体之间在多毛纲 Boccardia wellingtonensis 中基因表达的差异。
Sci Rep. 2021 Jul 22;11(1):14997. doi: 10.1038/s41598-021-94646-y.
10
Cold pain sensitivity is associated with single-nucleotide polymorphisms of / and .冷痛觉敏感性与 / 和 的单核苷酸多态性有关。
Mol Pain. 2021 Jan-Dec;17:17448069211002009. doi: 10.1177/17448069211002009.
冷激活瞬时受体电位通道 TRPM8 对冷却剂和脂质的感应结构基础。
Science. 2019 Mar 1;363(6430). doi: 10.1126/science.aav9334. Epub 2019 Feb 7.
4
Structural insights on TRPV5 gating by endogenous modulators.内源性调节剂对 TRPV5 门控的结构见解。
Nat Commun. 2018 Oct 10;9(1):4198. doi: 10.1038/s41467-018-06753-6.
5
Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314.使用季铵利多卡因衍生物QX-314靶向阻断表达TRPM8的神经元来实现选择性冷痛抑制。
Commun Biol. 2018 May 31;1:53. doi: 10.1038/s42003-018-0062-2. eCollection 2018.
6
Phospholipase C δ4 regulates cold sensitivity in mice.磷脂酶Cδ4调节小鼠的冷敏感性。
J Physiol. 2016 Jul 1;594(13):3609-28. doi: 10.1113/JP272321. Epub 2016 May 29.
7
A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.热适应的动态设定点需要磷脂酶C在体内介导对TRPM8的调节。
Pain. 2014 Oct;155(10):2124-33. doi: 10.1016/j.pain.2014.08.001. Epub 2014 Aug 7.
8
Phosphoinositide regulation of TRP channels.瞬时受体电位（TRP）通道的磷酸肌醇调节
Handb Exp Pharmacol. 2014;223:1143-76. doi: 10.1007/978-3-319-05161-1_18.
9
TRPM8.瞬时受体电位香草酸亚型8
Handb Exp Pharmacol. 2014;222:547-79. doi: 10.1007/978-3-642-54215-2_22.
10
Differential inhibition of the TRPM8 ion channel by Gαq and Gα 11.TRPM8 离子通道受 Gαq 和 Gα 11 的差异化抑制。
Channels (Austin). 2013 Mar-Apr;7(2):115-8. doi: 10.4161/chan.23466. Epub 2013 Jan 18.