Medical school, Alfaisal University, Riyadh, Saudi Arabia.
Division of neurosurgery, Neuroscience department, King Faisal specialist hospital and research centre, Riyadh, Saudi Arabia.
Neurochirurgie. 2021 Nov;67(6):579-586. doi: 10.1016/j.neuchi.2021.03.004. Epub 2021 Mar 22.
Liponeurocytoma is an uncommon tumor of the central nervous system. It is very rare for this tumor to originate within the lateral ventricle. In the context of the rarity of this tumor entity, this review article aims to summarize the clinical, radiological, and pathological features of lateral ventricular liponeurocytoma to facilitate its diagnosis and management.
Here, we conduct a systematic literature review using the Pubmed, Scopus, and Cochrane Library database for all cases of lateral ventricular liponeurocytoma. A case illustration complements this review.
The described cases from 1997 onward include 14 cases that have been published in full papers in the English literature. Six additional cases are reported in short English abstracts in full non-English papers, and one case was described in a central neurocytoma report. There is a definite male predominance of 70% (14 male) and a mean age of 37 years (range 24-62). Heterogenous enhancement and signals in magnetic resonant images (MRI) are the radiological characteristics. In all reported cases, the presence of lipocytes and fat vacuoles is considered the paramount histopathological feature. Total surgical resection was achieved in 80% (12 out of 15) of the cases. Only two cases (including ours) received radiation therapy. Recurrence was seen in two patients during follow-up that was treated by radiation therapy in one and surgery in the other. The proliferation index is mostly below 5% in all cases, with the Ki-67 range between<1% to 10%.
Lateral ventricular liponeurocytoma has been treated effectively by surgical resection in a limited number of cases. The decision for radiation therapy is based on a high proliferation index and tumor recurrence.
脂肪神经元细胞瘤是一种罕见的中枢神经系统肿瘤。起源于侧脑室内的脂肪神经元细胞瘤则更为罕见。鉴于该肿瘤实体的罕见性，本文旨在总结侧脑室内脂肪神经元细胞瘤的临床、影像学和病理学特征，以促进其诊断和治疗。
我们使用 Pubmed、Scopus 和 Cochrane Library 数据库对所有侧脑室内脂肪神经元细胞瘤病例进行了系统的文献回顾。通过一个病例说明对该综述进行了补充。
从 1997 年开始描述的病例中，有 14 例在英文文献中以全文形式发表，另有 6 例在非英文文献的全文英文摘要中报告，1 例在中枢神经细胞瘤报告中描述。存在明确的男性优势，占 70%（14 例男性），平均年龄为 37 岁（范围 24-62 岁）。磁共振成像（MRI）的影像学特征为不均匀强化和信号。在所有报道的病例中，脂肪细胞和脂肪空泡的存在被认为是最重要的组织病理学特征。80%（15 例中有 12 例）的病例完全手术切除。仅 2 例（包括我们的病例）接受了放射治疗。在随访中有 2 例患者出现复发，其中 1 例接受了放射治疗，另 1 例接受了手术治疗。所有病例的增殖指数大多低于 5%，Ki-67 指数范围为<1%至 10%。
在少数病例中，通过手术切除可有效治疗侧脑室内脂肪神经元细胞瘤。是否进行放射治疗取决于较高的增殖指数和肿瘤复发情况。
