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基于瓜尔胶的药物传递系统及其给药途径的最新进展。

Recent advances in guar gum based drug delivery systems and their administrative routes.

机构信息

Department of Chemistry, University of Delhi, Delhi 110 007, India.

Department of Chemistry, University of Delhi, Delhi 110 007, India.

出版信息

Int J Biol Macromol. 2021 Jun 30;181:653-671. doi: 10.1016/j.ijbiomac.2021.03.087. Epub 2021 Mar 22.

Abstract

Guar gum-based drug carrier systems have gained attention for the delivery of various therapeutic agents via different administration routes for attaining controlled and sustained release. Guar gum offers a safe and effective system for drug delivery due to its natural occurrence, easy availability, biocompatibility, and biodegradability, besides simple and mild preparation techniques. Furthermore, the possibility of using various routes such as oral, buccal, transdermal, intravenous, and gene delivery further diversify guar gum applications in the biomedical field. This review delineates the recent investigation on guar gum-based drug carrier systems like hydrogels, nanoparticles, nanocomposites, and scaffolds along with their related delivery routes. Also, the inclusion of data of the loading and subsequent release of the drugs enables to explore the noble and improved drug targeting therapies.

摘要

基于瓜尔胶的药物载体系统已经引起了人们的关注,因为它们可以通过不同的给药途径将各种治疗剂递送给患者,从而实现控制和持续释放。由于瓜尔胶的天然存在、易于获得、生物相容性和可生物降解性,以及简单温和的制备技术,因此它为药物输送提供了一种安全有效的系统。此外,由于可以使用各种途径,如口服、颊部、透皮、静脉内和基因传递,因此进一步使瓜尔胶在生物医学领域的应用多样化。本综述阐述了最近关于基于瓜尔胶的药物载体系统的研究进展,如水凝胶、纳米粒子、纳米复合材料和支架,以及它们相关的给药途径。此外,还包括了对药物的负载和随后释放的数据,从而能够探索更好的药物靶向治疗。

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