Department of Chemistry, Faculty of Engineering and Technology, SRM University, Kattankulathur, India.
Int J Biol Macromol. 2011 Aug 1;49(2):117-24. doi: 10.1016/j.ijbiomac.2011.04.022. Epub 2011 May 7.
Guar gum is a non-ionic polysaccharide that is found abundantly in nature and has many properties desirable for drug delivery applications. However, due to its high swelling characteristics in aqueous solution, the use of guar gum as delivery carriers is limited. Guar gum can be modified by derivatization, grafting and network formation to improve its property profile for a wide spectrum of biomedical applications. This review article is aimed at focusing the recent efforts and developments on guar gum and its derivatives as colon-specific, antihypertensive, protein and transdermal drug delivery systems. Based on the literatures reviewed, it is concluded that guar gum and its derivatives in the various forms such as coatings, matrix tablets, hydrogels and nano/microparticles can be exploited as potential carriers for targeted drug delivery.
瓜尔胶是一种天然存在的非离子型多糖，具有许多理想的药物传递应用特性。然而，由于其在水溶液中具有高溶胀特性，因此限制了瓜尔胶作为传递载体的使用。可以通过衍生化、接枝和网络形成来改性瓜尔胶，以改善其在广泛的生物医学应用中的性能特征。本文综述了瓜尔胶及其衍生物作为结肠特异性、抗高血压、蛋白质和透皮药物传递系统的最新研究进展。根据综述的文献，结论是瓜尔胶及其衍生物以各种形式，如涂层、基质片剂、水凝胶和纳米/微粒子，可以被开发为靶向药物传递的潜在载体。
