Prado Vinicius Costa, Moenke Kauani, Osmari Bárbara Felin, Pegoraro Natháli Schopf, Oliveira Sara Marchesan, Cruz Letícia
Laboratório de Tecnologia Farmacêutica, Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria CEP 97105-900, RS, Brazil.
Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105-900, RS, Brazil.
Pharmaceutics. 2023 Jan 14;15(1):285. doi: 10.3390/pharmaceutics15010285.
Irritant contact dermatitis is usually treated with corticosteroids, which cause expressive adverse effects. Sesamol is a phenolic compound with anti-inflammatory and antioxidant properties. This study was designed to evaluate a hydrogel containing sesamol-loaded ethylcellulose nanocapsules for the treatment of irritant contact dermatitis. The nanocapsules presented a size in the nanometric range, a negative zeta potential, a sesamol content close to the theoretical value (1 mg/mL), and a 65% encapsulation efficiency. Nanoencapsulation protected sesamol against UVC-induced degradation and increased the scavenging activity assessed by ABTS and DPPH radicals. The hydrogels were prepared by thickening the nanocapsule suspensions with guar gum (2.5%). The hydrogels maintained the nanometric size of the nanocapsules and a sesamol content of approximately 1 mg/g. The HET-CAM assay classified the hydrogels as nonirritating. The in vitro release of the hydrogel containing sesamol in the nanoencapsulated form demonstrated an initial burst effect followed by a prolonged sesamol release and a lower skin permeation in comparison with the hydrogel containing free sesamol. In addition, it exhibited the best anti-inflammatory effect in the irritant contact dermatitis model induced by croton oil, reducing ear edema and inflammatory cells infiltration, similar to dexamethasone (positive control). Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis.
刺激性接触性皮炎通常用皮质类固醇治疗，但会产生明显的不良反应。芝麻酚是一种具有抗炎和抗氧化特性的酚类化合物。本研究旨在评估一种含有负载芝麻酚的乙基纤维素纳米胶囊的水凝胶用于治疗刺激性接触性皮炎。纳米胶囊呈现纳米级尺寸、负的ζ电位、接近理论值的芝麻酚含量（1毫克/毫升）以及65%的包封率。纳米包封保护芝麻酚免受UVC诱导的降解，并增加了通过ABTS和DPPH自由基评估的清除活性。水凝胶通过用瓜尔胶（2.5%）增稠纳米胶囊悬浮液来制备。水凝胶保持了纳米胶囊的纳米尺寸和大约1毫克/克的芝麻酚含量。HET-CAM试验将水凝胶分类为无刺激性。与含有游离芝麻酚的水凝胶相比，含有纳米包封形式芝麻酚的水凝胶的体外释放显示出初始突释效应，随后是芝麻酚的持续释放和较低的皮肤渗透。此外，在巴豆油诱导的刺激性接触性皮炎模型中，它表现出最佳的抗炎效果，减轻耳部水肿和炎症细胞浸润，与地塞米松（阳性对照）相似。因此，含有纳米包封形式芝麻酚的水凝胶似乎在治疗刺激性接触性皮炎方面具有治疗潜力。
