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强毒性单纯疱疹病毒1型麦克雷毒株的基因组序列表明至少存在两种广泛使用的变异株。

Genome Sequence of the Virulent Model Herpes Simplex Virus 1 Strain McKrae Demonstrates the Presence of at Least Two Widely Used Variant Strains.

作者信息

Renner Daniel W, Parsons Lance, Shreve Jacob T, Engel Esteban A, Kuny Chad V, Enquist Lynn, Neumann Donna, Mangold Colleen, Szpara Moriah L

机构信息

Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.

出版信息

Microbiol Resour Announc. 2021 Mar 25;10(12):e01146-19. doi: 10.1128/MRA.01146-19.

DOI:10.1128/MRA.01146-19
PMID:33766904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7996463/
Abstract

Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of HSV-1 strain McKrae from the laboratory of James M. Hill to better understand the genetic differences between isolates.

摘要

单纯疱疹病毒1型（HSV-1）麦克雷毒株于1965年分离出来，被许多实验室所使用。此前已对三株HSV-1麦克雷毒株进行了测序，结果显示关键基因存在差异。我们对詹姆斯·M·希尔实验室的HSV-1麦克雷毒株基因组进行了测序，以更好地了解不同分离株之间的基因差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1af/7996463/4a9b37843f46/MRA.01146-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1af/7996463/4a9b37843f46/MRA.01146-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1af/7996463/4a9b37843f46/MRA.01146-19-f0001.jpg

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