Department of Therapeutic Dentistry, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.
Department of Pediatric Dentistry, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.
J Med Life. 2021 Jan-Mar;14(1):68-74. doi: 10.25122/jml-2020-0149.
This article highlights the results of a study of blood parameters in animals with simulated necrotizing ulcerative gingivitis and compares them, under the same conditions, with animals that received local treatment with a developed complex of antioxidant drugs. Following the work tasks, the nature of changes in the state of the antioxidant - prooxidant system and their influence on quantitative and functional indicators of markers of inflammatory intensity was analyzed and investigated during the pathological process in the background and without treatment with a developed complex. This work shows the changes of malonic dialdehyde concentration as an indicator of lipid peroxidation intensity in experimental animals, the level of catalase activity in the blood of animals, and antioxidant-prooxidant balance in the dynamics of necrotizing ulcerative gingivitis.
本文重点介绍了模拟坏死性溃疡性牙龈炎动物血液参数研究的结果,并在相同条件下,将其与接受局部抗氧化药物复合制剂治疗的动物进行了比较。根据工作任务,分析和研究了在病理过程中,在没有和有开发的抗氧化药物复合物治疗的背景下,抗氧化-促氧化剂系统状态的变化及其对炎症强度标志物的定量和功能指标的影响。这项工作表明了丙二醛浓度作为实验动物脂质过氧化强度指标的变化,动物血液中过氧化氢酶活性的水平,以及在坏死性溃疡性牙龈炎的动态中抗氧化-促氧化剂的平衡。