Wang Xin, Ma Rui, Shi Weimin, Wu Zhouwei, Shi Yuling
Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China.
Mol Ther Nucleic Acids. 2021 Mar 1;24:212-222. doi: 10.1016/j.omtn.2021.02.028. eCollection 2021 Jun 4.
Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed single-stranded structures lacking 5'-3' polarity and a polyadenine tail. Over recent years, a growing body of studies have been conducted to explore the roles of circRNAs in human diseases. Systemic lupus erythematosus (SLE) is a severe autoimmune disorder characterized by the presence of autoantibodies and excessive inflammation, which impact multiple organs. Recent advances have begun to shed light on the roles of circRNAs in SLE, providing fresh insights into the pathogenesis of SLE and the latent capacity for translation into clinical applications. Here, we briefly introduce these "star molecules" and summarize their roles in SLE. In addition, we outline the limitations of the current studies and raise prospects for future research.
环状RNA（circRNAs）是一类非编码RNA，具有共价闭合的单链结构，缺乏5'-3'极性和多聚腺苷酸尾巴。近年来，人们开展了越来越多的研究来探索circRNAs在人类疾病中的作用。系统性红斑狼疮（SLE）是一种严重的自身免疫性疾病，其特征是存在自身抗体和过度炎症，会影响多个器官。最近的进展已开始揭示circRNAs在SLE中的作用，为SLE的发病机制以及转化为临床应用的潜在能力提供了新的见解。在此，我们简要介绍这些“明星分子”并总结它们在SLE中的作用。此外，我们概述了当前研究的局限性并提出了未来研究的前景。
