Headache Unit, Department of Neurology, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria de La Princesa, Madrid, Spain.
Department of Neurology, Universidad Autónoma de Madrid, Madrid, Spain.
Neurol Sci. 2021 Dec;42(12):5087-5092. doi: 10.1007/s10072-021-05180-8. Epub 2021 Mar 26.
Face-to-face procedures have been postponed during COVID-19 pandemic. We aim to evaluate the impact of onabotulinumtoxinA follow-up delay in migraine during COVID-19 pandemic.
Subjective worsening, intensity of migraine attacks, and frequency of headache and migraine were retrospectively compared between patients with unmodified and interrupted onabotulinumtoxinA follow-up in Headache Units.
We included 67 patients with chronic migraine or high-frequency episodic migraine under onabotulinumtoxinA treatment, 65 (97.0%) female, 44.5 ± 12.1 years old. Treatment administration was voluntarily delayed in 14 (20.9%) patients and nine (13.4%) were unable to continue follow-up. Patients with uninterrupted follow-up during lockdown presented 7.6 and 8.1 less monthly days with headache (adjusted p = 0.017) and migraine attacks (adjusted p = 0.009) compared to patients whose follow-up was interrupted, respectively.
Involuntary delay of onabotulinumtoxinA follow-up in patients with migraine due to COVID-19 pandemic was associated with a higher frequency of headache and migraine attacks. Safe administration of onabotulinumtoxinA during lockdown should be promoted.
在 COVID-19 大流行期间，已经推迟了面对面的程序。我们旨在评估 COVID-19 大流行期间偏头痛患者中肉毒毒素 A 随访延迟对偏头痛的影响。
在头痛单元中，回顾性比较未修改和中断肉毒毒素 A 随访的偏头痛患者之间的主观恶化、偏头痛发作强度以及头痛和偏头痛的频率。
我们纳入了 67 名接受肉毒毒素 A 治疗的慢性偏头痛或高频发作性偏头痛患者，65 名（97.0%）为女性，年龄为 44.5 ± 12.1 岁。14 名（20.9%）患者自愿延迟治疗，9 名（13.4%）无法继续随访。与随访中断的患者相比，在封锁期间未中断随访的患者每月头痛（调整后的 p = 0.017）和偏头痛发作（调整后的 p = 0.009）天数分别减少了 7.6 和 8.1 天。
由于 COVID-19 大流行，偏头痛患者肉毒毒素 A 随访的非自愿延迟与头痛和偏头痛发作的频率增加有关。应促进在封锁期间安全管理肉毒毒素 A。
