Eisenberg E S
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Am J Kidney Dis. 1988 Jun;11(6):465-7. doi: 10.1016/s0272-6386(88)80080-5.
Five episodes of fungal peritonitis were treated by intraperitoneal instillation of 5-flucytosine (5-Fc) while the patients remained on their usual schedule of dialysis. Therapeutic, nontoxic dialysate and serum concentrations of 5-Fc were achieved. Although some patients transiently responded with improved symptoms, a drop in their dialysate WBC count and negative cultures, all patients required removal of their dialysis catheters for cure. It is concluded that intraperitoneal (IP) 5-Fc, as used in this study, is not efficacious in the treatment of fungal peritonitis.
5例真菌性腹膜炎患者在维持常规透析方案的同时，通过腹腔内注入5-氟胞嘧啶（5-Fc）进行治疗。5-Fc在透析液和血清中的浓度达到了治疗水平且无毒。尽管部分患者症状暂时改善，透析液白细胞计数下降且培养结果转为阴性，但所有患者均需拔除透析导管才能治愈。得出的结论是，本研究中使用的腹腔内（IP）5-Fc对真菌性腹膜炎治疗无效。
