Sazdovitch V, Verdier-Taillefer M H, Heinzlef O, Alamowitch S, Roullet E
Service de Neurologie, Hôpital Tenon, Paris.
Rev Neurol (Paris). 2000 Jul;156(6-7):638-40.
The empiric recurrence risk of multiple sclerosis (MS) of relatives of French MS patients is not known. Using a standardized interview, we collected the family histones of 357 consecutive patients followed at our MS clinic; adequate information was obtained on 4784 relatives up to the third degree. Thirty-five patients (9.8%) had a relative with MS. The risk-curve for relatives was the same as in other studies conducted with a similar methodology in Canada. England and Flanders. but the crude overall MS recurrence risk for relatives was lower in France. The genetic burden of MS may be lower in France than in areas of higher MS prevalence.
法国多发性硬化症（MS）患者亲属的经验性复发风险尚不清楚。我们采用标准化访谈，收集了在我们的MS诊所随访的357例连续患者的家族史；获得了多达三级亲属中4784人的充分信息。35例患者（9.8%）有亲属患MS。亲属的风险曲线与在加拿大、英国和佛兰德斯采用类似方法进行的其他研究相同，但法国亲属的总体MS复发风险原始值较低。法国MS的遗传负担可能低于MS患病率较高的地区。
