Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Department of Urology, Xianyang Central Hospital, Xianyang, 710061, Shaanxi, China.
Lasers Med Sci. 2022 Feb;37(1):555-561. doi: 10.1007/s10103-021-03297-y. Epub 2021 Mar 26.
A 450-nm blue laser may be suitable to treat benign prostate hyperplasia (BPH) due to its haemoglobin absorption characteristic. The present study compared a novel high-power 450-nm semiconductor blue laser with other lasers marketed for in vitro soft tissue ablation, to evaluate the safety and efficacy of the 450-nm laser in BPH surgery. With the in vitro tissues on an experimental platform in water, the vaporization efficiency and coagulation layer thickness of the novel 450-nm laser and commercially available 532-nm, 980-nm, and 1470-nm lasers were measured at the same power (120 W). The damage to the adjacent tissue and the working noise were also measured. The vaporization efficiency was proved to be 450-nm laser > 532-nm laser > 1470-nm laser > 980-nm laser. Comparison of coagulation layer thickness was as follow: 980-nm laser > 1470-nm laser > 532-nm laser > 450-nm laser. The degree of tissue damage caused by the 450-nm and 532-nm lasers increased with the decrease in distance and increase in time (these are safe when a sufficient distance and short irradiation time are maintained). The heating ability of 980-nm and 1470-nm lasers was much greater than that of 450-nm and 532-nm lasers. The working noise was lower in 450-nm and 1470-nm lasers. The novel 450-nm laser has the advantages of highly efficient tissue vaporization, creating a thin coagulation layer, and low working noise. These characteristics suggest that the novel 450-nm laser may be a promising choice for the surgical treatment of BPH.
450nm 蓝光激光由于其血红蛋白吸收特性，可能适用于治疗良性前列腺增生（BPH）。本研究比较了一种新型高功率 450nm 半导体蓝光激光与其他市售用于体外软组织消融的激光，以评估 450nm 激光在 BPH 手术中的安全性和有效性。在水实验平台上的离体组织上，以相同的功率（120W）测量了新型 450nm 激光和市售的 532nm、980nm 和 1470nm 激光的汽化效率和凝固层厚度。还测量了对相邻组织的损伤和工作噪声。结果表明，汽化效率为 450nm 激光>532nm 激光>1470nm 激光>980nm 激光。凝固层厚度的比较结果如下：980nm 激光>1470nm 激光>532nm 激光>450nm 激光。450nm 和 532nm 激光引起的组织损伤程度随距离的减小和时间的增加而增加（当保持足够的距离和短的照射时间时是安全的）。980nm 和 1470nm 激光的加热能力远大于 450nm 和 532nm 激光。450nm 和 1470nm 激光的工作噪声较低。新型 450nm 激光具有高效组织汽化、形成薄凝固层和低工作噪声的优点。这些特性表明，新型 450nm 激光可能是治疗 BPH 的一种有前途的选择。
