Postgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Endocrine. 2021 Jul;73(1):160-165. doi: 10.1007/s12020-021-02700-6. Epub 2021 Mar 26.
Increasing evidence suggests that the FGF-Klotho endocrine system and the somatotropic system (pituitary and extra-pituitary GH) may have important metabolic and immune relationships, thus contributing to the pathophysiology of aging-related disorders, including diabetes, atherosclerosis, and cancer. The status of these interactions in isolated GH deficiency (IGHD) is unknown. The objective of this study was to assess the response of both FGF21 and β-Klotho levels to a standard meal in a homogeneous group of adults with congenital untreated IGHD due to a homozygous mutation in the GHRH receptor gene.
In a cross-sectional study, we measured the levels of FGF21 and β-Klotho, before and 30, 60, 120, and 180 min after a standardized test meal in 20 (11 males) IGHD and 20 (11 males) age-matched controls. Areas under the curves (AUC) of FGF21 and β-Klotho were calculated.
Baseline levels of FGF21 were similar, but baseline levels of β-Klotho were lower in IGHD subjects. The IGHD individuals exhibited lower AUC for FGF21 and β-Klotho levels than control subjects. There was a positive correlation between IGF1 and β-Klotho levels in the pooled groups. No correlation was found between IGF1 and FGF21 levels.
Subjects with lifetime, untreated IGHD exhibit reduced FGF21 and β-Klotho levels response to a mixed meal. This difference may have consequences on metabolism and aging.
越来越多的证据表明，FGF-Klotho 内分泌系统和生长激素系统（垂体和垂体外 GH）可能具有重要的代谢和免疫关系，从而有助于与衰老相关疾病的病理生理学，包括糖尿病、动脉粥样硬化和癌症。这些相互作用在孤立性生长激素缺乏症（IGHD）中的状态尚不清楚。本研究的目的是评估在由于生长激素释放激素受体基因纯合突变导致的先天性未治疗的 IGHD 成人的同质组中，FGF21 和 β-Klotho 水平对标准餐的反应。
在一项横断面研究中，我们在 20 例（11 名男性）IGHD 和 20 例（11 名男性）年龄匹配的对照者中，在标准化测试餐后 30、60、120 和 180 分钟测量 FGF21 和 β-Klotho 的水平。计算 FGF21 和 β-Klotho 的曲线下面积（AUC）。
IGHD 受试者的基础 FGF21 水平相似，但基础 β-Klotho 水平较低。IGHD 个体的 FGF21 和 β-Klotho 水平 AUC 低于对照组。在合并组中，IGF1 和 β-Klotho 水平之间存在正相关。IGF1 和 FGF21 水平之间没有相关性。
终生未经治疗的 IGHD 受试者对混合餐的 FGF21 和 β-Klotho 水平反应降低。这种差异可能对代谢和衰老有影响。
