Newsome D A, Michels R G
Louisiana State University Medical Center School of Medicine, LSU Eye Center, New Orleans 70112.
Am J Ophthalmol. 1988 Jun 15;105(6):596-602. doi: 10.1016/0002-9394(88)90050-5.
We used monoclonal antibodies against specific T cell, B cell, and macrophage antigens to detect immune system cells in the vitreous gel of retinitis pigmentosa patients. Vitreous samples were obtained by biopsy from three patients and by dissection from eight postmortem donor eyes. All samples contained CD4, T helper and CD8, suppressor cells, activated T cells, some B cells, and macrophages. About one third of the cells were nonreactive. Vitreous gel from normal controls contained mostly nonreactive cells with a few macrophages and rare T cells. These observations further indicated the nature of the cellular reaction in retinitis pigmentosa and characterized the biomicroscopically visible particulate bodies characteristically seen in the vitreous gel of these patients.
我们使用针对特定T细胞、B细胞和巨噬细胞抗原的单克隆抗体，来检测色素性视网膜炎患者玻璃体凝胶中的免疫系统细胞。通过活检从3例患者获取玻璃体样本，并从8例死后供体眼中通过解剖获取样本。所有样本均含有CD4、辅助性T细胞和CD8、抑制性细胞、活化T细胞、一些B细胞和巨噬细胞。约三分之一的细胞无反应性。正常对照的玻璃体凝胶主要含有无反应性细胞，伴有少量巨噬细胞和罕见的T细胞。这些观察结果进一步表明了色素性视网膜炎中细胞反应的性质，并对这些患者玻璃体凝胶中特征性可见的生物显微镜下颗粒体进行了特征描述。
