Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, People's Republic of China.
Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Nanotechnology. 2021 Apr 16;32(27). doi: 10.1088/1361-6528/abf26c.
Tea tree oil, a natural antibacterial compound, cannot be used effectively because of its volatile nature. In this work, a biocompatible carrier was prepared and loaded with tea tree essential oil. The carrier was prepared via the electrostatic or chemical action of aminated mesoporous silica and sodium rosin for achieving a low volatilization rate of tea tree essential oil. A synergistic antibacterial effect was observed between sodium rosin and tea tree essential oil. This method utilized the positive charge of the amino group and the condensation reaction with the carboxyl group to achieve physical and chemical interactions with sodium rosin. Fourier Transform Infrared, Brunauer-Emmet-Teller, Zeta potential, SEM, TEM, and TG were performed to characterize the structure and properties of the samples. Compared to the electrostatic effect, the chemically modified system exhibited a longer sustained release, and the sustained release curve followed the Korsmeyer-Peppas release model. Also, the antibacterial properties of the chemically modified system exhibited better minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) respectively, the MIC and MBC forwere 0.3 mg mland 0.6 mg mlrespectively, forwere 0.15 mg mland 0.3 mg mlrespectively. More strikingly, the sample also demonstrated long-term antibacterial performance. Therefore, this work provides a new way for the delivery of volatile antibacterial drugs to achieve sustained-release and long-lasting antibacterial effects.
茶树油是一种天然的抗菌化合物，但由于其挥发性，无法有效使用。在这项工作中，制备了一种生物相容性载体并负载茶树精油。载体通过氨基化介孔硅酸钠与松香酸钠之间的静电或化学反应制备，以实现茶树精油的低挥发性。松香酸钠和茶树精油之间表现出协同抗菌作用。该方法利用氨基的正电荷和与羧基的缩合反应实现与松香酸钠的物理和化学相互作用。采用傅里叶变换红外光谱（FTIR）、BET、Zeta 电位、SEM、TEM 和 TG 对样品的结构和性能进行了表征。与静电作用相比，化学改性体系表现出更长的缓释效果，并且缓释曲线遵循 Korsmeyer-Peppas 释放模型。此外，化学改性体系的抗菌性能表现出更好的最小抑菌浓度（MIC）和最小杀菌浓度（MBC），MIC 和 MBC 分别为 0.3 mg/ml 和 0.6 mg/ml，0.15 mg/ml 和 0.3 mg/ml。更引人注目的是，该样品还表现出长期的抗菌性能。因此，这项工作为挥发性抗菌药物的输送提供了一种新的方法，以实现缓释和持久的抗菌效果。
