Wan Xuejuan, Zhuang Lulu, She Boxi, Deng Yuanming, Chen Dazhu, Tang Jiaoning
Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China; Guangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen 518060, China.
Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:323-30. doi: 10.1016/j.msec.2016.04.058. Epub 2016 Apr 19.
Monodisperse silver nanoparticles (Ag NPs) were facilely loaded on the inner and outer surface of hierarchical wrinkled mesoporous silica (WMSs) via an in situ chemical reduction, and the antibacterial capacity of the obtained nanocomposite was investigated in detail. Typical sulfydryl-functionalized wrinkled mesoporous silica nanoparticle with radical pore channels was firstly prepared through sol-gel technique with cetyltrimethylammonium bromide (CTAB) as the templating surfactant. After sulfonation of the as-prepared WMSs, Ag(+) ions were then densely locked up on the inner and outer surface of WMSs via electrostatic interactions. Well distributed Ag NPs (ca. 3-5nm) on WMSs without any agglomeration were finally obtained via a simple in situ reduction reaction with sodium borohydride. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) test indicated that the obtained products can achieve durable and much better antibacterial performance both against Gram-negative bacterium Escherichia coli (E. coli) and Gram-positive bacterium Staphylococcus aureus (S. aureus) comparing to pure colloidal silver nanoparticles, which rendered them as favorable candidate for the development of effective antibacterial agents.
通过原位化学还原法，将单分散银纳米颗粒（Ag NPs）轻松负载在分级褶皱介孔二氧化硅（WMSs）的内外表面，并详细研究了所得纳米复合材料的抗菌能力。首先以十六烷基三甲基溴化铵（CTAB）为模板表面活性剂，通过溶胶 - 凝胶技术制备了具有典型巯基官能化且带有径向孔道的褶皱介孔二氧化硅纳米颗粒。在对制备好的WMSs进行磺化后，Ag(+)离子通过静电相互作用密集地锁定在WMSs的内外表面。最后，通过与硼氢化钠的简单原位还原反应，在WMSs上获得了分布均匀且无任何团聚的Ag NPs（约3 - 5nm）。最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测试表明，与纯胶体银纳米颗粒相比，所得产物对革兰氏阴性菌大肠杆菌（E. coli）和革兰氏阳性菌金黄色葡萄球菌（S. aureus）均能实现持久且更好的抗菌性能，这使其成为开发有效抗菌剂的理想候选材料。
